Abstract
Various doses of the neurotoxin 6-hydroxydopamine (6-OHDA) were infused into the substantia nigra-ventromedial tegmental area, caudateputamen nucleus, and red nucleus. A maximum of four successively occurring zones of neuropathology could by detected at all injection sites: (1) A zone of complete absence of neural, glial, and vascular elements due to tissue displacement by the cannula, (2) an area of glial cells, developing over time, which surrounded the cannula tract, (3) a region exhibiting virtually complete loss of neuronal elements, and (4) a zone of selective neuropathological reaction or cellular loss in which some neurons were affected and others were not. All investigators who have histochemically and/or histologically evaluated the effects of intracerebrally administered 6-OHDA agree on the existence and genesis, some non-selective process, of the first three zones. Although some scientists maintain that the fourth zone is where 6-OHDA operates selectively, data are presented in this report that other, well-established processes can account for neuropathology beyond zone 3. Prominent among these are retrograde and anterograde degeneration, ischemia as a function of interruption of blood supply, and nonselective traum...Continue Reading
References
Jan 1, 1975·Journal of Neural Transmission·L L ButcherL Bilezikjian
Dec 10, 1971·Brain Research·P L McGeerV Wickson
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·L L ButcherG K Hodge
Dec 15, 1973·The Journal of Comparative Neurology·R A Miller, N L Strominger
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Jul 9, 1971·Brain Research·R Y MooreA Heller
Aug 30, 1973·Brain Research·C SoteloJ Glowinski
Aug 30, 1973·Brain Research·Y AgidC Sotelo
Oct 12, 1973·Brain Research·T Hökfelt, U Ungerstedt
Aug 1, 1972·Journal of the Neurological Sciences·L J PoirierA Kitsikis
Dec 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·D Jacobowitz, R Kostrzewa
Feb 1, 1970·Journal of Neurochemistry·N J Uretsky, L L Iversen
Mar 15, 1971·Experientia·A LjungdahlC Sachs
Jun 18, 1971·Science·R Heikkila, G Cohen
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Nov 1, 1963·Biochemistry·G COHEN, P HOCHSTEIN
Mar 1, 1964·Acta Physiologica Scandinavica·A DAHLSTROEM, K FUXE
Sep 1, 1964·Acta Physiologica Scandinavica·K JOHANSEN
Jan 1, 1971·Tissue & Cell·R L Gulley, R L Wood
Citations
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·G K Hodge, L L Butcher
Apr 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·E G Markova, M A Kacharava
Mar 10, 1980·Brain Research·A D LoewyW M Panneton
Jan 25, 1991·Brain Research·K E LeighK A Rogers
Jul 1, 1985·Developmental Biology·F W PehlemannM Berry
Aug 1, 1978·European Journal of Pharmacology·L L Butcher, R C Rogers
Dec 1, 1986·Experimental Neurology·G Carre, C Harley
Apr 1, 1977·Physiology & Behavior·S P Grossman, L Grossman
Jan 1, 1977·Pharmacology, Biochemistry, and Behavior·S P GrossmanA Halaris
Apr 1, 1977·Pharmacology, Biochemistry, and Behavior·L J McDermottS P Grossman
May 1, 1979·Pharmacology, Biochemistry, and Behavior·G K Hodge, L L Butcher
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Aug 1, 1987·Neuroscience Research·K NakaiT Kasamatsu
May 1, 1993·Neuroscience Research·T Hattori
Jan 1, 1987·Neurochemistry International·G L Willis, G C Smith
May 17, 1982·Neuroscience Letters·P H CooperL L Butcher
Jan 1, 1981·Neuroscience·A Smiałowski, M Smiałowska
Aug 1, 1986·Brain Research Bulletin·G L Willis, G C Smith
Jan 7, 2000·Neuroscience·H GurdenT M Jay
Nov 9, 2001·The International Journal of Neuroscience·R W RodriguesG Chadi
Aug 1, 1981·Journal of Pharmaceutical Sciences·D E Nichols
Jan 15, 2016·Journal of Neuroscience Research·Anna-Maija PenttinenMikko Airavaara
May 1, 1979·The Journal of Comparative Neurology·T Kasamatsu, J D Pettigrew
Aug 11, 1980·Brain Research·F HeftiR J Wurtman
May 27, 1977·Brain Research·S M AntelmanM Lin
Sep 1, 1991·Experimental Neurology·J N Joyce
Nov 18, 1977·Brain Research·P CampochiaroJ T Coyle
Feb 10, 1987·Brain Research·G L WillisG C Smith
Jan 1, 1989·Acta Neuropathologica·C TengvarY Olsson
May 27, 1977·Brain Research·R Schwarcz, J T Coyle