Degenerative processes after punctate intracerebral administration of 6-hydroxydopamine.

Journal of Neural Transmission
L L Butcher

Abstract

Various doses of the neurotoxin 6-hydroxydopamine (6-OHDA) were infused into the substantia nigra-ventromedial tegmental area, caudateputamen nucleus, and red nucleus. A maximum of four successively occurring zones of neuropathology could by detected at all injection sites: (1) A zone of complete absence of neural, glial, and vascular elements due to tissue displacement by the cannula, (2) an area of glial cells, developing over time, which surrounded the cannula tract, (3) a region exhibiting virtually complete loss of neuronal elements, and (4) a zone of selective neuropathological reaction or cellular loss in which some neurons were affected and others were not. All investigators who have histochemically and/or histologically evaluated the effects of intracerebrally administered 6-OHDA agree on the existence and genesis, some non-selective process, of the first three zones. Although some scientists maintain that the fourth zone is where 6-OHDA operates selectively, data are presented in this report that other, well-established processes can account for neuropathology beyond zone 3. Prominent among these are retrograde and anterograde degeneration, ischemia as a function of interruption of blood supply, and nonselective traum...Continue Reading

References

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Citations

Apr 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·E G Markova, M A Kacharava
Aug 1, 1978·European Journal of Pharmacology·L L Butcher, R C Rogers
Dec 1, 1986·Experimental Neurology·G Carre, C Harley
Apr 1, 1977·Physiology & Behavior·S P Grossman, L Grossman
May 1, 1979·Pharmacology, Biochemistry, and Behavior·G K Hodge, L L Butcher
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
May 1, 1993·Neuroscience Research·T Hattori
Aug 1, 1981·Journal of Pharmaceutical Sciences·D E Nichols
Jan 15, 2016·Journal of Neuroscience Research·Anna-Maija PenttinenMikko Airavaara
Nov 18, 1977·Brain Research·P CampochiaroJ T Coyle
May 27, 1977·Brain Research·R Schwarcz, J T Coyle

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