PMID: 8943049Nov 26, 1996Paper

Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes

Proceedings of the National Academy of Sciences of the United States of America
J E Van Leeuwen, K P Kearse

Abstract

Recent evidence indicates that newly synthesized major histocompatibility complex (MHC) class I proteins interact with calnexin, a transmembrane endoplasmic reticulum protein specific for certain glycoproteins bearing monoglucosylated glycans. Here, we studied the association of newly synthesized class I proteins with calreticulin, a soluble calnexin-related ER protein, in murine T cells. We found that, unlike calnexin-class I interactions, calreticulin assembly with class I proteins was markedly decreased in the absence of beta 2 microglobulin expression and that calreticulin associated with a subset of class I glycoforms distinct from those assembled with calnexin but similar to those bound to TAP (transporter associated with antigen processing) proteins. Finally, these studies show that deglucosylation of N-linked glycans is important for dissociation of class I proteins from both calreticulin and TAP and that the vast majority of newly synthesized class I proteins associated with calreticulin are simultaneously assembled with TAP. The data demonstrate that calnexin and calreticulin chaperones assemble with distinct MHC class I assembly intermediates in the ER and show that glycan processing is functionally coupled to releas...Continue Reading

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K GalvinM Ozturk
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F HochstenbachM B Brenner
Jan 11, 1989·Nucleic Acids Research·L Zhu, P P Jones
Jan 1, 1995·Annual Review of Biochemistry·M T Heemels, H Ploegh
Nov 3, 1995·The Journal of Biological Chemistry·A Ora, A Helenius
Mar 3, 1995·The Journal of Biological Chemistry·W M NauseefR A Clark
Apr 1, 1994·Glycobiology·K W MoremenA Herscovics
Jan 1, 1994·Methods in Enzymology·G P Kaushal, A D Elbein
Mar 1, 1994·Trends in Biochemical Sciences·J J BergeronD B Williams
Jan 1, 1993·Annual Review of Cell Biology·M R Jackson, P A Peterson
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C HammondA Helenius

❮ Previous
Next ❯

Citations

Jun 26, 1999·European Journal of Immunology·N BangiaP Cresswell
Sep 26, 2002·Virus Research·Philippa M O'Brien, M Saveria Campo
Nov 26, 2002·Virus Research·M Saveria Campo
Nov 18, 1998·Current Opinion in Structural Biology·E S Trombetta, A Helenius
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pamela A WearschPeter Cresswell
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wei ZhangPeter Cresswell
May 22, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S V Fromm, R Ehrlich
Aug 16, 2002·Molecular Biology of the Cell·Christopher M CabralRichard N Sifers
Mar 14, 2008·Molecular Biology of the Cell·Breanna S IrelandDavid B Williams
Jan 13, 2000·Immunological Reviews·J C Solheim
Jan 13, 2000·Immunological Reviews·P CresswellG Diedrich
May 23, 1998·Annual Review of Immunology·E Pamer, P Cresswell
Apr 30, 2008·Cancer Cell International·Charles A GulloGerrard Teoh
Oct 16, 2001·Cell Stress & Chaperones·J H ChoS Natori
Oct 21, 2004·Biological Chemistry·Cynthia Anne WrightSebastian Springer
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·S LiP Wang
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Laura MancinoMalini Raghavan
Sep 27, 2005·Immunological Reviews·Tim Elliott, Anthony Williams
Aug 16, 2005·Molecular Immunology·Martine T BarelEmmanuel J H J Wiertz
Sep 20, 2000·Redox Report : Communications in Free Radical Research·W M NauseefM Goedken
Aug 31, 2000·Annual Review of Biochemistry·A J Parodi
Jun 25, 1998·Current Biology : CB·E A Hughes, P Cresswell
Jun 25, 1998·Current Biology : CB·N A Morrice, S J Powis
Jan 23, 2002·Oncogene·G Hossein AshrafiM Saveria Campo
Aug 30, 2005·Critical Reviews in Biochemistry and Molecular Biology·Eelco van Anken, Ineke Braakman
Apr 19, 2008·The Journal of Biological Chemistry·Aline MartayanPatrizio Giacomini
Nov 9, 2000·The Journal of Biological Chemistry·A UjvariD N Hebert
Apr 25, 2000·The Journal of Biological Chemistry·U G DanilczykD B Williams
Apr 26, 2002·Tissue Antigens·H R TurnquistJ C Solheim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.