Degradable particulate composite reinforced with nanofibres for biomedical applications

Acta Biomaterialia
E D PinhoN M Neves

Abstract

Nanofibre-based structures and their composites are increasingly being studied for many biomedical applications, including tissue engineering scaffolds. These materials enable architectures resembling the extracellular matrix to be obtained. The search for optimized supports and carriers of cells is still a major challenge for the tissue engineering field. The main purpose of this work is to develop a novel composite structure that combines microparticles and nanofibres in reinforced polymeric microfibres. This innovative combination of materials is obtained by melting extrusion of a particulate composite reinforced with chitosan nanofibre meshes (0.05 wt.%) produced by the electrospinning technique. The reinforced microfibres were analysed by scanning electron microscopy and showed a considerable alignment of the chitosan nanofibres along the longitudinal main axis of the microfibre composite structure. The tensile mechanical properties revealed that the introduction of the nanofibre reinforcement in the particulate microfibre composite increased the tensile modulus by up to 70%. The various structures were subjected to swelling and degradation tests immersed in an isotonic saline solution at 37 degrees C. The presence of chit...Continue Reading

References

Sep 25, 2004·Journal of Materials Science. Materials in Medicine·E T BaranR L Reis
Jun 24, 2005·Journal of Biomedical Materials Research. Part a·Rebecca A MacDonaldJan P Stegemann
Nov 8, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Paolo P Provenzano, Ray Vanderby
Dec 20, 2005·Journal of Materials Science. Materials in Medicine·K TuzlakogluR L Reis
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
May 17, 2006·Acta Biomaterialia·Laure NotinAlain Domard
May 22, 2008·Journal of Tissue Engineering and Regenerative Medicine·Lauren S SefcikEdward A Botchwey
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·V M CorreloR L Reis
Feb 1, 2005·Nanotechnology·Ryuji InaiSeeram Ramakrishna

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Citations

Jul 30, 2010·Tissue Engineering. Part a·Albino MartinsNuno M Neves
Jan 30, 2010·Journal of Tissue Engineering and Regenerative Medicine·Albino MartinsNuno M Neves
Jan 27, 2015·Journal of Tissue Engineering and Regenerative Medicine·Sajedeh KhorshidiSeeram Ramakrishna
Feb 24, 2015·International Journal of Pharmaceutics·J PelipenkoJ Kristl
Nov 11, 2011·Journal of Biomaterials Applications·Yang-Hee KimByong-Taek Lee
Oct 25, 2016·Journal of the Mechanical Behavior of Biomedical Materials·S C CifuentesJ L González-Carrasco
Nov 26, 2010·Biomacromolecules·M L Alves da SilvaN M Neves

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