Degradable polyphosphazene/poly(alpha-hydroxyester) blends: degradation studies

Biomaterials
Archel M A AmbrosioC T Laurencin

Abstract

Biomaterials based on the polymers of lactic acid and glycolic acid and their copolymers are used or studied extensively as implantable devices for drug delivery, tissue engineering and other biomedical applications. Although these polymers have shown good biocompatibility, concerns have been raised regarding their acidic degradation products, which have important implications for long-term implantable systems. Therefore, we have designed a novel biodegradable polyphosphazene/poly(alpha-hydroxyester) blend whose degradation products are less acidic than those of the poly(alpha-hydroxyester) alone. In this study, the degradation characteristics of a blend of poly(lactide-co-glycolide) (50:50 PLAGA) and poly[(50% ethyl glycinato)(50% p-methylphenoxy) phosphazene] (PPHOS-EG50) were qualitatively and quantitatively determined with comparisons made to the parent polymers. Circular matrices (14mm diameter) of the PLAGA, PPHOS-EG50 and PLAGA-PPHOS-EG50 blend were degraded in non-buffered solutions (pH 7.4). The degraded polymers were characterized for percentage mass loss and molecular weight and the degradation medium was characterized for acid released in non-buffered solutions. The amounts of neutralizing base necessary to bring ab...Continue Reading

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Citations

Jan 17, 2004·International Journal of Pharmaceutics·Richard A GravesTarun K Mandal
Apr 23, 2003·Advanced Drug Delivery Reviews·S LakshmiC T Laurencin
May 6, 2006·Tissue Engineering·Maria Teresa ConconiPier Paolo Parnigotto
Apr 19, 2008·Journal of Biomaterials Science. Polymer Edition·L MoroniC A van Blitterswijk
Jan 24, 2013·Critical Reviews in Biomedical Engineering·Ami R AminiSyam P Nukavarapu
Aug 16, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Changhong ZhangThomas Boland
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad AkramMuhammad Saleem
Jun 13, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Changhong ZhangXuejun Wen
Jan 1, 2004·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·A M AmbrosioC T Laurencin
Aug 8, 2006·Biomaterials·Yongzhong WangDavid L Kaplan
Jan 24, 2009·Journal of Biomedical Materials Research. Part a·Meng DengCato T Laurencin
Nov 14, 2014·Critical Reviews in Analytical Chemistry·A GhaffarSj van der Wal
May 26, 2004·International Journal of Pharmaceutics·M Acemoglu
Jun 10, 2017·Regenerative Engineering and Translational Medicine·Kenneth S OgueriCato T Laurencin
Aug 20, 2019·Regenerative Engineering and Translational Medicine·Kenneth S OgueriCato T Laurencin
Apr 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul Strasser, Ian Teasdale
Nov 10, 2005·Chemical Reviews·Chang-Sik Ha, Joseph A Gardella
May 9, 2006·Biomacromolecules·Alexander K Andrianov, Alexander Marin

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