Degradable, thermo-, pH- and redox-sensitive hydrogel microcapsules for burst and sustained release of drugs

International Journal of Pharmaceutics
Marcin MackiewiczMarcin Karbarz

Abstract

Polymer microcapsules offer a possibility of storing increased amounts of drugs. Appropriate design and composition of the microcapsules allow tuning of the drug-release process. In this paper, we report on synthesis of hydrogel microcapsules sensitive to temperature and pH and degradable by glutathione and hydrogen peroxide. Microcapsules were based on thermo-responsive poly(N-isopropylacrylamide) and degradable cystine crosslinker, and were synthesized by applying precipitation polymerization. Such way of polymerization was appropriately modified to limit the crosslinking in the microcapsule center. This led to a possibility of washing out the pNIPA core at room temperature and the formation of a capsule. Microcapsules revealed rather high drug-loading capacity of ca. 17%. The degradation of the microcapsules by the reducing agent (GSH) and the oxidizing agent (H2O2) was confirmed by using the DLS, UV-Vis, SEM and TEM techniques. Depending on pH and concentration of the reducing/oxidizing agents a fast or slow degradation of the microcapsules and a burst or long-term release of doxorubicin (DOX) were observed. The DOX loaded microcapsules appeared to be cytotoxic against A2780 cancer cells similarly to DOX alone, while unload...Continue Reading

Citations

Nov 5, 2019·Frontiers in Chemistry·Dao-Yang FanZhong-Jun Liu
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·N R PopovaV K Ivanov
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Czerniecka-KubickaMarek Pyda
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shirin MollazadehMostafa Yazdimamaghani
May 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhi ZhengHua Wei
Sep 10, 2021·International Journal of Pharmaceutics·Xuexue LiuSong Shen

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