Degradable thermoresponsive core cross-linked micelles: fabrication, surface functionalization, and biorecognition

Langmuir : the ACS Journal of Surfaces and Colloids
Xiaoze JiangRavin Narain

Abstract

We report on the fabrication of core cross-linked (CCL) micelles possessing thermoresponsive and degradable cores and biocompatible coronas cofunctionalized with carbohydrate and biotin moieties. Well-defined poly(2-aminoethylmethacrylamide) (PAEMA) homopolymer was first synthesized in a controlled fashion via the reversible addition-fragmentation chain transfer (RAFT) process. CCL micelles comprising of well-solvated PAEMA coronas and thermoresponsive cores were then obtained in a one-pot manner via RAFT copolymerization of N-isopropylacrylamide (NIPAM) and bis(2-methacryloyloxyethyl) disulfide (DSDMA) difunctional monomers by employing PAEMA as the macro-RAFT agent. In the presence of dithiothreitol (DTT), the obtained CCL micelles can be disintegrated into unimers due to the cleavage of disulfide cross-linkers, whereas deswelling of micellar cores can be achieved via heating above the phase transition temperature of PNIPAM. Thus, the release profiles of this type of nanocarriers are expected to be triggered by temperature and thiols or a combination of both. Furthermore, primary amine residues located within coronas of CCL micelles have been further exploited for surface functionalization with biotin and carbohydrate moietie...Continue Reading

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Citations

Dec 17, 2011·Bioconjugate Chemistry·Neha BhucharRavin Narain
Aug 31, 2012·Bioconjugate Chemistry·Rajesh SunaseeRavin Narain
Nov 1, 2010·Therapeutic Delivery·Himanshu BhattacharjeeGeorge C Wood
Sep 26, 2013·Advanced Drug Delivery Reviews·Yuanpei LiKit S Lam
Jul 7, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Liang YuanHanying Zhao
May 14, 2011·Expert Opinion on Drug Delivery·Zhenqing Li, Jianjun Guan
Feb 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ru ChengZhiyuan Zhong
Nov 28, 2012·Advanced Healthcare Materials·Yi LiDoo Sung Lee
Mar 25, 2011·Advanced Materials·Taolei Sun, Guangyan Qing
Apr 30, 2016·ACS Applied Materials & Interfaces·S PanjaS Chattopadhyay
Mar 29, 2013·ACS Macro Letters·Zhonghai ZhangJianjun Cheng
Feb 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ji LiuChristine Jérôme
Mar 4, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Xuejuan WanShiyong Liu

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