Degradation and transformation of 17α-estradiol in water-sediment systems under controlled aerobic and anaerobic conditions

Environmental Toxicology and Chemistry
Joseph A RobinsonJon F Ericson

Abstract

One of the principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains estradiol benzoate and trenbolone acetate, is 17α-estradiol. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17α-[14 C]-estradiol in 2 representative water-sediment systems each under aerobic and anaerobic conditions. The same transformation products-estriol, 17β-estradiol, and estrone-were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of estrone and 17β-estradiol were determined, along with the DT50 values of 17α-estradiol and the total drug (17α-estradiol + 17β-estradiol + estrone). The results indicate that 17 α-[14 C]-estradiol was more persistent under anaerobic conditions than under aerobic conditions and that 17 α-[14 C]-estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phases) and for the total residues (17α-estradiol, 17β-estradiol, and ...Continue Reading

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Citations

Feb 14, 2019·Environmental Science and Pollution Research International·Weiwei YuMinne Zhang
Nov 11, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Marco VighiKeith R Solomon
Feb 25, 2017·Environmental Toxicology and Chemistry·Jane P Staveley
Oct 10, 2020·Environmental Science. Processes & Impacts·Daniela RechsteinerThomas D Bucheli
Nov 19, 2020·Journal of Agricultural and Food Chemistry·Shuo YangJingjing Tang

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