Degradation and transformation of 17α-trenbolone in aerobic water-sediment systems

Environmental Toxicology and Chemistry
Joseph A RobinsonJon F Ericson

Abstract

Synovex® ONE is an extended-release implant containing the active ingredients estradiol benzoate and trenbolone acetate for use in beef steers and heifers. Trenbolone acetate is rapidly hydrolyzed in cattle to form 17β-trenbolone and its isomer, 17α-trenbolone, which are further transformed to a secondary metabolite, trendione. As part of the environmental assessment for the use of Synovex ONE, data were generated to characterize the fate of 17α-trenbolone, which is the principal metabolite found in cattle excreta, in the environment. A study was conducted to determine the degradation and transformation of [14 C]-17α-trenbolone in 2 representative water-sediment systems under aerobic conditions. The same transformation products, 17β-trenbolone and trendione, were formed, principally in the sediment phase, in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of 17β-trenbolone and trendione were determined, along with the DT50 values of the parent compound and the total drug (17α-trenbolone + 17β-trenbolone + trendione). The DT50 values for the total system (aqueous and sediment phase) and for the total residues (17α-trenbolone + 17β-trenbolone + trendione) in the 2 syste...Continue Reading

References

Jul 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J PottierI P Reynolds
Mar 5, 2004·Environmental Health Perspectives·Ana M SotoCarlos Sonnenschein
Dec 16, 2004·Environmental Science & Technology·Edward P KolodziejDavid L Sedlak
May 25, 2006·Environmental Science & Technology·Kathleen M JensenGerald T Ankley
Mar 3, 2007·Environmental Science & Technology·Stephen R HutchinsDennis D Fine
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen A KiddRobert W Flick
Sep 11, 2007·The Science of the Total Environment·Alan S KolokLouis J Guillette
Feb 1, 2011·Journal of Contaminant Hydrology·Shannon Bartelt-HuntDavid Miesbach
Sep 1, 2011·Environmental Science & Technology·Heather E GallChad T Jafvert
Sep 8, 2011·Environmental Science & Technology·D Scott MansellDavid L Sedlak
Jan 3, 2012·Environmental Science & Technology·Jeffrey H WriterLarry B Barber
Apr 24, 2012·Environmental Science & Technology·Wei ZhengScott A Bradford
Aug 1, 2012·Environmental Toxicology and Chemistry·Allen W OlmsteadSigmund J Degitz
Aug 15, 2012·Environmental Science and Pollution Research International·Bryson E FinchPhilip N Smith
Aug 12, 2014·The Science of the Total Environment·Jodi L SangsterShannon L Bartelt-Hunt

❮ Previous
Next ❯

Citations

Feb 25, 2017·Environmental Toxicology and Chemistry·Jane P Staveley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.