Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: comparison with control hydrophobic one

Journal of Materials Science. Materials in Medicine
Se Heang OhJin Ho Lee

Abstract

Porous PLGA/PVA scaffolds as hydrophilized PLGA scaffolds for tissue engineering applications were fabricated by a novel melt-molding particulate leaching method (non-solvent method). The prepared scaffolds exhibited highly porous and open-cellular pore structures with almost same surface and interior porosities (pore size, 200-300 microm; porosity, about 90%). The in vitro degradation behavior of the PLGA and PLGA/PVA scaffolds was compared at 37 degrees C in PBS (pH 7.4) with and without the solution change everyday to see the effect of solution pH as well as scaffold hydrophilicity on the degradation behavior. The changes in dimension, molecular weight, mechanical properties (maximum load and modulus), and morphology of the scaffolds were examined with degradation time. The degradation behavior of the PLGA and PLGA/PVA scaffolds was further investigated in vivousing a rat model (subcutaneously implantation). It was observed that both PLGA and PLGA/PVA scaffolds in decreasing pH condition (PBS no change) showed faster degradation than those in constant pH condition (PBS change everyday), owing to the enhanced intramolecular depolymerization by the increment of chain hydrophilicity caused by carboxylate groups as well as the a...Continue Reading

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Citations

Aug 27, 2010·Journal of Materials Science. Materials in Medicine·Pinar YilgorVasif Hasirci
Jan 31, 2007·Journal of Biomaterials Science. Polymer Edition·Se Heang OhJin Ho Lee
Nov 3, 2011·Journal of Long-term Effects of Medical Implants·Ami R AminiSyam P Nukavarapu
May 27, 2014·Biotechnology Advances·Lara Yildirimer, Alexander M Seifalian
Aug 12, 2014·Expert Opinion on Drug Delivery·Vuk Uskoković, Tejal A Desai
Feb 27, 2015·Journal of Pharmaceutical Sciences·Sibel Bozdağ PehlivanNurşen Ünlü
Dec 15, 2012·Journal of Tissue Engineering and Regenerative Medicine·Sharath Kumar C SundararajDavid A Puleo
Jun 10, 2014·Journal of Biomedical Materials Research. Part a·Yanzhu YangYuhong Xu
Mar 8, 2012·Journal of Tissue Engineering and Regenerative Medicine·P YilgorV Hasirci
Mar 13, 2014·Journal of Tissue Engineering and Regenerative Medicine·Hye Yun KimGilson Khang
Jun 4, 2014·Journal of Tissue Engineering and Regenerative Medicine·Ga Young LeeGilson Khang
May 26, 2016·ACS Applied Materials & Interfaces·S Geetha PriyaAshok Kumar
Sep 8, 2017·Journal of Biomedical Materials Research. Part a·Yong Sang ChoYoung-Sam Cho
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·Esmaiel JabbariWeijie Xu
Feb 13, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Aurelien ForgetAnton Blencowe
Nov 25, 2017·Advanced Healthcare Materials·Cláudia MartinsBruno Sarmento
Mar 7, 2020·Polymers·Víctor Santos-RosalesCarlos A García-González
Oct 20, 2016·Tissue Engineering and Regenerative Medicine·Hyun Ki MinJin Ho Lee
Jan 12, 2021·Applied Physics Reviews·Liqun NingVahid Serpooshan
Jun 3, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Chang Mo HwangSang-Hoon Lee

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