Degradation behaviors of bioabsorbable P3/4HB monofilament suture in vitro and in vivo

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Xianyu ChenKaitian Xu

Abstract

The biodegradable behaviors of monofilament suture made from bacterial biopolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3/4HB) was investigated both in lipase solution and by implant into rat tergal muscles. Results showed that the monofilament suture lost its tensile strength gradually accompanied by decrease of molecular weight. The suture retained approximately 65% of its original strength after lipase degradation for 12 weeks, whereas the molecular weight decreased from 4.5 x 10(5) to 3.8 x 10(5). However, the crystallinity of the suture, after lipase degradation for 12 weeks, increased from 27 to 33%. This may ascribe to improve orientation arrangement of molecular chain in the monofilament after the fragment from amorphous regions dissolved in the buffer solution. The roughness of surface morphology increased with degradation. Rat implantation showed no remarkable tissue responses during in vivo degradation. Foreign body reactions were much milder than chromic catgut, which is one of the most common commercially available sutures.

References

Jan 1, 1981·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·R S Bartholomew
Apr 1, 1994·International Journal of Biological Macromolecules·Y Saito, Y Doi
Jul 1, 1994·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·M S TaylorJ Heller
Oct 31, 2000·Biomaterials·J C Middleton, A J Tipton
Nov 23, 2000·The Journal of Thoracic and Cardiovascular Surgery·B H SmaillA J Galbraith
Aug 27, 2002·Biomaterials·Friederike von BurkersrodaAchim Göpferich
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·E I ShishatskayaS N Efremov
Feb 7, 2007·Expert Review of Medical Devices·Sabeel P ValappilIpsita Roy
Oct 31, 2007·Journal of Materials Science. Materials in Medicine·Elzbieta Pamula, Elzbieta Menaszek
Dec 29, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Basse AsplundJöns Hilborn
Apr 30, 2008·Acta Biomaterialia·Meng DengRobert Vetrecin

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Citations

Jan 14, 2021·Biomedical Physics & Engineering Express·Md Lukman HakimShazid Md Sharker

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