Degradation in insulin sensitivity with increasing severity of the metabolic syndrome in obese postmenopausal women

Diabetes, Obesity & Metabolism
Antony D KarelisRémi Rabasa-Lhoret

Abstract

We investigated the relationship between insulin sensitivity and the graded increase in the number of features of the metabolic syndrome in a cross-sectional sample of obese postmenopausal women. We hypothesized that insulin sensitivity would deteriorate with an increased number of metabolic syndrome phenotypes. Insulin sensitivity was measured in 75 obese postmenopausal women (age: 57.3 +/- 5.3 years; BMI: 32.8 +/- 4.5 kg/m2) by using both the hyperinsulinaemic-euglycaemic clamp and the homeostasis model assessment (HOMA-IR). Features of the metabolic syndrome included visceral fat (>130 cm2), HDL-cholesterol (<1.29 mmol/l), fasting triglycerides (> or =1.7 mmol/l), blood pressure (> or =130/> or =85 mmHg) and fasting glucose (> or =6.1 mmol/l). Participants were classified into three categories based on the presence of metabolic syndrome phenotypes: 0-1 vs. 2 vs. > or =3 features of the metabolic syndrome. We found that insulin sensitivity decreased in a graded fashion (12.19 +/- 3.2 vs. 11.80 +/- 2.3 vs. 9.29 +/- 2.6 mg/min/FFM) and HOMA-IR increased in a similar manner (2.95 +/- 1.1 vs. 3.28 +/- 1.3 vs. 4.65 +/- 2.2), as the number of features of the metabolic syndrome increased from 0-1 to > or =3. When insulin sensitivity...Continue Reading

References

Apr 14, 2000·Journal of Cardiopulmonary Rehabilitation·M BrochuP A Ades
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Jul 30, 2002·Diabetes·Anthony J G HanleyUNKNOWN Insulin Resistance Atherosclerosis Study
Sep 17, 2002·The American Journal of Cardiology·Jane E B Reusch
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Amalia GastaldelliEle Ferrannini
May 22, 2003·Metabolism: Clinical and Experimental·Martin BrochuEric T Poehlman
Aug 13, 2003·Respiratory Care Clinics of North America·Daniel Baram
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Martha L CruzMichael I Goran
Feb 27, 2004·The American Journal of Clinical Nutrition·Ian JanssenRobert Ross
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Jun 18, 2004·The New England Journal of Medicine·Samuel KleinB Selma Mohammed

❮ Previous
Next ❯

Citations

Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Belinda ElishaRémi Rabasa-Lhoret
May 9, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Antony D KarelisRémi Rabasa-Lhoret
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Antony D KarelisRémi Rabasa-Lhoret
Aug 12, 2008·Molecular and Cellular Endocrinology·Rodrigo Palazzo De Almeida BarrosUbiratan Fabres Machado
Mar 21, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael R DeschenesEmily K Glass
Jul 17, 2014·Medicine and Science in Sports and Exercise·Martin SénéchalSteven N Blair
Oct 28, 2006·JAAPA : Official Journal of the American Academy of Physician Assistants·Eileen M Van DykeCynthia Ulshafer
Oct 26, 2021·Frontiers in Endocrinology·Jianbo YuShunqi Wang
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.