Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector

Microbiology and Immunology
Madoka SakaiKeizo Tomonaga

Abstract

Accumulation of amyloid β (Aβ40 and Aβ42) in the brain is a characteristic of Alzheimer's disease (AD). Because neprilysin (NEP) is a major Aβ-degrading enzyme, NEP delivery in the brain is a promising gene therapy for AD. Borna disease virus (BoDV) vector enables long-term transduction of foreign genes in the central nerve system. Here, we evaluated the proteolytic ability of NEP transduced by the BoDV vector and found that the amounts of Aβ40 and Aβ42 significantly decreased, which suggests that NEP expressed from the BoDV vector is functional to degrade Aβ.

References

Jul 1, 1992·Nature Genetics·J Hardy
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T BrieseW I Lipkin
Aug 1, 1994·Journal of Virology·P A SchneiderW I Lipkin
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·T BrieseW I Lipkin
Dec 16, 1998·Journal of Virology·T KohnoM Nakai
Oct 31, 2001·Neuron·D J Selkoe
May 3, 2003·Nature Reviews. Genetics·Clare E ThomasMark A Kay
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·W Taylor KimberlyDennis J Selkoe
Jun 10, 2003·Alzheimer Disease and Associated Disorders·Anders WimoEva von Strauss
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuhisa IwataTakaomi C Saido
Jun 2, 2005·Annals of Neurology·Masahiro MaruyamaHidetada Sasaki
Mar 28, 2008·Brain Pathology·James Scott MinersSeth Love
Apr 12, 2008·The American Journal of Pathology·Salim S El-AmouriMark S Kindy
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Mar 19, 2013·Scientific Reports·Nobuhisa IwataTakaomi C Saido
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Masayuki HorieKeizo Tomonaga
Oct 31, 2014·Annals of Clinical and Translational Neurology·Takakuni MakiMasafumi Ihara
Nov 20, 2014·Journal of Alzheimer's Disease : JAD·Melanie HüttenrauchOliver Wirths
Feb 13, 2016·Cell·Bart De Strooper, Eric Karran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.