PMID: 6168746Aug 1, 1981Paper

Degradation of basic protein and Wolfgram protein in central nervous system by soluble enzymes of human peripheral polymorphonuclear leucocytes

Journal of the Neurological Sciences
S C Rastogi, J Clausen

Abstract

The present communication describes the ability of soluble enzymes (SE) of peripheral polymorphonuclear leucocytes of control and multiple sclerosis (MS) patients to degrade major myelin proteins of MS and control myelin. MS and control SE degraded in situ both Wolfgram protein (WP) and basic protein (BP) of isolated myelin. No differences were found between the action of control and MS patients SE on myelin. However, significantly less degradation of BP and WP in control myelin compared to that in MS myelin was found. Only 30% of SE samples (both control and MS) degraded significant amounts of proteolipid protein in myelin. It is postulated that SE associated demyelination in MS may be a factor contributing to the demyelinating process.

References

Nov 1, 1977·Acta Neurologica Scandinavica·S C RastogiG E Jensen
Jan 1, 1978·Advances in Experimental Medicine and Biology·M E SMith
Jan 1, 1978·Advances in Experimental Medicine and Biology·W T NortonS Gordon
Jun 1, 1979·Acta Neurologica Scandinavica·S C RastogiT Fog
Sep 1, 1975·Human Pathology·J Prineas
Oct 1, 1976·Journal of the Neurological Sciences·M L CuznerA N Davison
Dec 23, 1976·The New England Journal of Medicine·S R CohenG M McKhann
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Jan 1, 1970·Acta Neurologica Scandinavica·P J RiekkinenU K Rinne
Feb 14, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·S C Rastogi, J Clausen
Nov 1, 1976·Journal of Neurochemistry·M E Smith

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Citations

Oct 1, 1984·Journal of Neurocytology·W Beuche, R L Friede
Dec 1, 1982·Journal of Neuroimmunology·V HukkanenH Frey
Aug 19, 1983·Neuroscience Letters·I Singh, A K Singh
Jan 1, 1989·The European Journal of Neuroscience·E R LunnS Gordon
Nov 19, 2002·Perceptual and Motor Skills·Alberto Montare

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