Degradation of caspase-activated DNase by the ubiquitin-proteasome system

Biochimica Et Biophysica Acta
Tadamiki TsurutaYoko Hirata

Abstract

DNA fragmentation is one of the most characteristic features of apoptotic cells and caspase-activated DNase (CAD) is considered to be a major nuclease responsible for DNA fragmentation. CAD forms a complex with its inhibitor (ICAD), which is also required for the functional folding of CAD, leading to CAD stabilization in cells. In this paper, we investigated the involvement of the ubiquitin-proteasome system in CAD stability. The expression and ubiquitination of CAD was remarkably increased by MG132 treatment in the absence of ICAD. These results suggest that CAD protein may be preferentially degraded by the ubiquitin-proteasome system in the absence of ICAD to maintain protein quality control.

References

Sep 15, 1994·Biochemical and Biophysical Research Communications·S Tanuma, D Shiokawa
Apr 1, 1994·Experimental Cell Research·R BertrandY Pommier
May 20, 1998·Current Biology : CB·R HalenbeckL T Williams
Sep 29, 1998·Journal of Neurochemistry·Y HirataK Kiuchi
Dec 19, 1998·The EMBO Journal·A Ciechanover
Oct 21, 1999·Biochemical and Biophysical Research Communications·J S McCartyP Li
Mar 14, 2000·The Journal of Biological Chemistry·H SakahiraS Nagata
Mar 21, 2000·Nature·I Schubert, U Wobus
Jul 26, 2000·The Journal of Cell Biology·D LechardeurG L Lukacs
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·H OubrahimP B Chock
Feb 19, 2002·Trends in Cell Biology·Jianhua Zhang, Ming Xu
Apr 10, 2002·The Journal of Biological Chemistry·Victor T SolovyanMichael J Courtney
Jul 13, 2002·Trends in Biochemical Sciences·Douglas M CyrCam Patterson
Mar 26, 2003·Cell Death and Differentiation·S NagataH Fukuyama
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Shigeo MurataKeiji Tanaka
Mar 18, 2005·Annual Review of Immunology·Shigekazu Nagata
Jan 24, 2007·Neurochemistry International·Tadamiki TsurutaYoko Hirata

❮ Previous
Next ❯

Citations

Feb 1, 2012·Biochimie·Thangaiyan RadhigaKodukkur Viswanathan Pugalendi
Jul 22, 2014·European Journal of Medicinal Chemistry·Ana KolarevicAndrija Smelcerovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.