Degradation of deoxyribonucleic acid by guinea pig epidermal extracts

Archives of Dermatological Research
T MiyagawaH Urabe

Abstract

The capability of guinea pig epidermal extracts to hydrolyze deoxyribonucleic acid has been studied. The results of investigation by gel filtration on Sephadex G-75 column and by viscometry on the mode of hydrolysis of deoxyribonucleic acid by epidermal extracts revealed that deoxyribonucleic acid was degraded by both endonuclease and exonuclease activities. The exhaustive digestion by epidermal extracts yielded the complete degradation of deoxyribonucleic acid to mononucleosides or further metabolites. The enzyme systems involved in the deoxyribonucleic acid degradation include at least an endonuclease, an exonuclease and a phosphatase.

References

Nov 1, 1967·The Journal of Investigative Dermatology·F ZarubaE M Farber
Jan 29, 1968·Biochimica Et Biophysica Acta·M Carrara, G Bernardi
Feb 1, 1967·The Journal of Investigative Dermatology·J De Bersaques
Aug 1, 1962·The Journal of Investigative Dermatology·C HODGSON

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Citations

Dec 28, 1981·Biochimica Et Biophysica Acta·M AnaiT Miyagawa
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·T Miyagawa, Y Eguchi
Jul 13, 2001·Pharmacology & Therapeutics·C J Wraight, P J White
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R C DukeJ J Cohen
Mar 23, 2011·International Journal of Pharmaceutics·Thomas SchmidtsFrank Runkel
Mar 1, 1977·The British Journal of Dermatology·T MiyagawaH Urabe
Mar 1, 1982·The British Journal of Dermatology·W T Gibson
Oct 1, 1978·International Journal of Dermatology·P M Davison, M A Karasek
May 1, 1983·The Journal of Investigative Dermatology·R K Freinkel, T N Traczyk

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