Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp

Biological Chemistry
Maria Rapala-KozikAndrzej Kozik

Abstract

The secretion of proteolytic enzymes by pathogenic microorganisms is one of the most successful strategies used by pathogens to colonize and infect the host organism. The extracellular microbial proteinases can seriously deregulate the homeostatic proteolytic cascades of the host, including the kinin-forming system, repeatedly reported to be activated during bacterial infection. The current study assigns a kinin-releasing activity to secreted proteinases of Candida spp. yeasts, the major fungal pathogens of humans. Of several Candida species studied, C. parapsilosis and C. albicans in their invasive filamentous forms are shown to produce proteinases which most effectively degrade proteinaceous kinin precursors, the kininogens. These enzymes, classified as aspartyl proteinases, have the highest kininogen-degrading activity at low pH (approx. 3.5), but the associated production of bradykinin-related peptides from a small fraction of kininogen molecules is optimal at neutral pH (6.5). The peptides effectively interact with cellular B2-type kinin receptors. Moreover, kinin-related peptides capable of interacting with inflammation-induced B1-type receptors are also formed, but with a reversed pH dependence. The presented variability...Continue Reading

References

Jul 1, 1990·Infection and Immunity·H KaminishiY Hagihara
Oct 15, 1987·Thrombosis Research·D A JohnsonA J Barrett
Aug 1, 1996·The Journal of Experimental Medicine·H HerwaldL Björck
Feb 6, 1998·World Journal of Surgery·D A Dean, K W Burchard
Jun 25, 1998·Infection and Immunity·F De BernardisW A Fonzi
Sep 4, 1999·FEMS Microbiology Letters·M H RodierJ L Jacquemin
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·P StaibJ Morschhäuser
Sep 27, 2000·Biochimica Et Biophysica Acta·G KoelschX Lin
May 12, 2001·Infection and Immunity·E MattssonL Björck
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Allen P KaplanMichael Silverberg
Sep 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Julian R NaglikBernhard Hube
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Heiko HerwaldLars Björck
Sep 2, 2004·Cellular Microbiology·Julian NaglikBernhard Hube
Nov 9, 2004·Toxicon : Official Journal of the International Society on Toxinology·Shin-ichi MiyoshiSumio Shinoda
Feb 12, 2005·Advances in Immunology·Kusumam Joseph, Allen P Kaplan
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Stephen B PhagooDavid Warburton
Apr 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Antoni StadnickiRobert W Colman
Apr 9, 2005·BMC Infectious Diseases·Ming-Fang ChengHsiu-Jung Lo
Aug 27, 2005·The Journal of Antimicrobial Chemotherapy·Malcolm D Richardson
Feb 21, 2006·FEMS Immunology and Medical Microbiology·André Luis Souza dos SantosRosangela Maria de Araújo Soares
Jun 1, 2006·Blood·Sara H BengtsonHeiko Herwald
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahisa ImamuraKeinosuke Okamoto
Sep 13, 2007·Thrombosis and Haemostasis·Inga-Maria FrickHeiko Herwald
Sep 13, 2007·Thrombosis and Haemostasis·Simone Bergmann, Sven Hammerschmidt
Jan 10, 2008·International Immunopharmacology·Anna BarbaszAndrzej Kozik
Jan 10, 2008·International Immunopharmacology·Maria Rapala-KozikAndrzej Kozik
Jan 10, 2008·International Immunopharmacology·Radka ZubakovaUlrich Hilgenfeldt
Oct 6, 2009·International Immunopharmacology·Dorit K NäglerAlexander Faussner
Sep 20, 1938·The Journal of General Physiology·M L Anson

❮ Previous
Next ❯

Citations

May 5, 2012·Neurochemistry International·Ibeth Guevara-Lora
Aug 22, 2016·The Journal of Pain : Official Journal of the American Pain Society·Megan L FalsettaRichard P Phipps
Nov 16, 2017·Molecular Oral Microbiology·M Rapala-KozikA Kozik
Jan 25, 2011·Mycopathologia·Iwona Yike
Oct 22, 2019·Frontiers in Molecular Neuroscience·Bingyuan JiYili Wu
Oct 7, 2017·Frontiers in Cellular and Infection Microbiology·Marcin ZawrotniakMaria Rapala-Kozik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.