PMID: 8961558Dec 1, 1996Paper

Degradation of lactoferrin by periodontitis-associated bacteria

FEMS Microbiology Letters
K R Alugupalli, S Kalfas

Abstract

The degradation of human lactoferrin by putative periodontopathogenic bacteria was examined. Fragments of lactoferrin were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and measured by densitometry. The degradation of lactoferrin was more extensive by Porphyromonas gingivalis and Capnocytophaga sputigena, slow by Capnocytophaga ochracea, Actinobacillus actinomycetemcomitans and Prevotella intermedia, and very slow or absent by Prevotella nigrescens, Campylobacter rectus, Campylobacter sputorum, Fusobacterium nucleatum ssp. nucleatum, Capnocytophaga gingivalis, Bacteroides forsythus and Peptostreptococcus micros. All strains of P. gingivalis tested degraded lactoferrin. The degradation was sensitive to protease inhibitors, cystatin C and albumin. The degradation by C. sputigena was not affected by the protease inhibitors and the detected lactoferrin fragments exhibited electrophoretic mobilities similar to those ascribed to deglycosylated forms of lactoferrin. Furthermore a weak or absent reactivity of these fragments with sialic acid-specific lectin suggested that they are desialylated. The present data indicate that certain bacteria colonizing the periodontal pocket can degrade lactoferrin. The presen...Continue Reading

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Citations

May 29, 2002·Oral Microbiology and Immunology·S GuanS Shizukuishi
May 20, 2009·Antimicrobial Agents and Chemotherapy·Hiroyuki WakabayashiHiromasa Yoshie
Jun 27, 2009·The Lancet Infectious Diseases·Richard L OehlerSandra Gompf
Jan 26, 2007·International Journal of Antimicrobial Agents·Anne Jolivet-GougeonMartine Bonnaure-Mallet
Apr 27, 2004·Periodontology 2000·Neil M O'Brien-SimpsonEric C Reynolds
Aug 8, 2006·The Journal of Veterinary Medical Science·Yumiko KomineKen-ichi Komine
Aug 26, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyuki KamiyaTetsuya Matsumoto
Mar 4, 2006·Journal of Periodontology·Jörg EberhardJens M Schröder
May 15, 2002·FEMS Microbiology Letters·K-P Leung, Shawn P Folk
Jan 18, 2005·FEMS Microbiology Reviews·Teresa OlczakCaroline Attardo Genco
Feb 16, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hiroyuki WakabayashiHiromasa Yoshie
Nov 28, 2020·Frontiers in Cellular and Infection Microbiology·Hao-Jiang ZuoXiu-Ying Hu
Jan 20, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nicholas K H OstanAnthony B Schryvers

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