PMID: 38617Jan 1, 1978

Degradation of low-density lipoproteins (LDL) and LDL - protamine complexes by lysosomal protease

Acta Biologica Academiae Scientiarum Hungaricae
Z Skrzydlewski, K Worowski


Native LDL are degraded by the protease of the lysosomal extract but they are not sensitive to isolated cathepsin D. Protamine increases the sensitivity of LDL to the effect of lysosomal protease and makes them sensitive to the effect of cathepsin D. Degradation of LDL by lysosomal protease is most intensive between pH 4.0 and 4.5 but in case of LDL bound with protamine it is most intensive at pH 4.5--5.0.

Related Concepts

Hydrogen-Ion Concentration
Peptide Hydrolases
Protamine Sulfate (USP)

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.