Degradation of sulfonamide antibiotics by Microbacterium sp. strain BR1 - elucidating the downstream pathway

New Biotechnology
Benjamin RickenBoris A Kolvenbach

Abstract

Microbacterium sp. strain BR1 is among the first bacterial isolates which were proven to degrade sulfonamide antibiotics. The degradation is initiated by an ipso-substitution, initiating the decay of the molecule into sulfur dioxide, the substrate specific heterocyclic moiety as a stable metabolite and benzoquinone imine. The latter appears to be instantaneously reduced to p-aminophenol, as that in turn was detected as the first stable intermediate. This study investigated the downstream pathway of sulfonamide antibiotics by testing the strain's ability to degrade suspected intermediates of this pathway. While p-aminophenol was degraded, degradation products could not be identified. Benzoquinone was shown to be degraded to hydroquinone and hydroquinone in turn was shown to be degraded to 1,2,4-trihydroxybenzene. The latter is assumed to be the potential substrate for aromatic ring cleavage. However, no products from the degradation of 1,2,4-trihydroxybenzene could be identified. There are no signs of accumulation of intermediates causing oxidative stress, which makes Microbacterium sp. strain BR1 an interesting candidate for industrial waste water treatment.

References

Jan 1, 1992·Toxicology and Applied Pharmacology·T J MonksD G Graham
Mar 22, 2000·Chemical Research in Toxicology·J L BoltonT J Monks
May 3, 2000·Journal of Applied Microbiology·A ChauhanR K Jain
Apr 2, 2003·Environmental Science & Technology·Marc M HuberUrs von Gunten
Jul 15, 2011·Applied Microbiology and Biotechnology·Boris A KolvenbachPhilippe F X Corvini
Oct 25, 2011·Applied and Environmental Microbiology·Helene BoujuBoris A Kolvenbach
Nov 13, 2012·Journal of Bioenergetics and Biomembranes·Yoshiki KabashimaJunshi Sakamoto
Jul 10, 2013·Applied and Environmental Microbiology·Benjamin RickenBoris A Kolvenbach
Sep 23, 2014·Journal of Hazardous Materials·Patrícia J M ReisOlga C Nunes

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Citations

Nov 12, 2020·Applied Microbiology and Biotechnology·Olga C NunesPhilippe F-X Corvini
Aug 15, 2019·New Biotechnology·Ana C ReisPhilippe F X Corvini
Jun 28, 2019·Environmental Science & Technology·Akashdeep Singh OberoiHui Lu
Nov 6, 2021·World Journal of Microbiology & Biotechnology·Zhenzhen ZhaoHai Yan

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