PMID: 6167674Apr 1, 1981Paper

Degradation of the P0, P1, and Pr proteins in peripheral nervous system myelin by plasmin: implications regarding the role of macrophages in demyelinating diseases

Journal of Neurochemistry
W CammerW T Norton

Abstract

Activated macrophages secrete a variety of neutral proteinases, including plasminogen activator. Since macrophages are implicated in primary demyelination in the peripheral nervous system (PNS) in Guillain-Barré syndrome and experimental allergic neuritis, we have investigated the ability of plasmin and of conditioned media from cultured macrophages, in the presence of plasminogen, to degrade the proteins in bovine and rat PNS myelin. The results indicate that (a) the major glycoprotein P0 and the basic P1 and Pr proteins in PNS myelin are extremely sensitive to plasmin, perhaps more so than is the basic protein in CNS myelin; (b) the initial product of degradation of P0 by plasmin has a molecular weight higher than that of the "X" protein; (c) large degradation products of P0 are relatively insensitive to further degradation; and (d) the neuritogenic P2 protein in PNS myelin is quite resistant to the action of plasmin. Results similar to those with plasmin were obtained with conditioned media from macrophages and macrophage-like cell lines together with plasminogen activator, and the degradation of the PNS myelin proteins, Po and P1, under these conditions was inhibited by p-nitrophenylguanidinobenzoate, an inhibitor of plasmi...Continue Reading

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Citations

Feb 1, 1995·Muscle & Nerve·H P HartungK V Toyka
Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Jan 1, 1984·Neurochemical Research·V ZabrenetzkyP S Spencer
Jul 1, 1984·Journal of the Neurological Sciences·H A John, I F Purdom
Jun 1, 1986·Journal of the Neurological Sciences·Y GobanM Kameyama
Nov 1, 1982·Journal of Neuroimmunology·F A Tansey, C F Brosnan
Mar 1, 1991·Journal of Neuroimmunology·M SchabetH Wiethölter
Oct 1, 1992·Journal of Neuroimmunology·H P HartungK V Toyka
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Feb 5, 2000·Progress in Neurobiology·R C MelcangiL Martini
Sep 1, 1996·The Journal of Cell Biology·M H Wong, M T Filbin
Sep 4, 2013·BioMed Research International·Kishan Kumar Nyati, Roopanshi Nyati
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C G FernandesL A Pereira
Jan 30, 2008·Current Protocols in Cell Biology·Jorge N Larocca, Williams T Norton
Sep 1, 1990·Neurochemical Research·K SchottH Wiethölter
Oct 1, 1984·Neurochemical Research·J N Whitaker, J M Seyer

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