Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9

FEBS Letters
K ImaiY Okada

Abstract

The susceptibility of vitronectin (Vn) purified from human plasma to digestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesting 8-, 30- and 44-fold more preferentially than MMP-2, -3, and -9, respectively. These data suggest that MMP-2, -3, -7 and -9 may be responsible for the pathological degradation and/or normal turnover of Vn.

References

May 1, 1991·The Journal of Investigative Dermatology·H HintnerS M Breathnach
Jan 1, 1991·Annual Review of Cell Biology·K T Preissner
Aug 1, 1988·Cell Structure and Function·T YatohgoM Hayashi
Oct 15, 1993·The Biochemical Journal·Q NguyenP J Roughley
Sep 6, 1994·Annals of the New York Academy of Sciences·J F Woessner

❮ Previous
Next ❯

Citations

Nov 24, 2011·Molecular Neurobiology·Inge Van HoveLieve Moons
Oct 24, 2003·Molecular and Cellular Neurosciences·Catherine VaillantNicole Thomasset
Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Masahiko ZukaShogo Katsuda
Jan 30, 2014·Cancers·Antonietta Rosella Farina, Andrew Reay Mackay
Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Tomoko MiyakeKuniyo Inouye
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
May 17, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·B J GrindelM C Farach-Carson
Aug 13, 2013·Periodontology 2000·Georgina S Butler, Christopher M Overall
Aug 7, 2012·Journal of Neurochemistry·Inge Van HoveLieve Moons
Oct 22, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V CantemirP R Brauer
Feb 4, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valérie ParadisPierre Bedossa
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B SteffensenH Larjava
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J F Woessner
Apr 21, 2020·Clinical Interventions in Aging·Előd Ernő NagyBéla Kovács
Apr 4, 2021·International Journal of Molecular Sciences·Matiss OzolsMichael J Sherratt
May 24, 2005·Biochimica Et Biophysica Acta·Mikael Björklund, Erkki Koivunen
Sep 16, 2004·Journal of Agricultural and Food Chemistry·Yuko MutaKuniyo Inouye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.