PMID: 3771642Oct 1, 1986Paper

Degradation rates of acetylcholine receptors can be modified in the postjunctional plasma membrane of the vertebrate neuromuscular junction

The Journal of Cell Biology
M M SalpeterT Levitt-Gilmour

Abstract

Denervation of vertebrate muscle causes an acceleration of acetylcholine receptor turnover at the neuromuscular junction. This acceleration reflects the composite behavior of two populations of receptors: "original receptors" present at the junction at the time of denervation, and "new receptors" inserted into the denervated junction to replace the original receptors as they are degraded (Levitt, T. A., and M. M. Salpeter, 1981, Nature (Lond.), 291:239-241). The present study examined the degradation rate of original receptors to determine whether reinnervation could reverse the effect of denervation. Sternomastoid muscles in adult mice were denervated by either cutting or crushing the nerve, and the nerves either allowed to regenerate or ligated to prevent regeneration. The original receptors were labeled with 125I-alpha-bungarotoxin at the time of denervation, and their degradation rate followed by gamma counting. We found that when the nerve was not allowed to regenerate, the degradation decreased from a t1/2 of approximately 8-10 d to one of approximately 3 d (as reported earlier for denervated original receptors) and remained at that half-life throughout the experiment (approximately 36 d). If the axons were allowed to reg...Continue Reading

References

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Citations

Oct 1, 1991·Muscle & Nerve·D M Wetzel, M M Salpeter
Mar 18, 1994·Brain Research. Developmental Brain Research·F FillouxJ M McIntosh
Aug 1, 1990·Trends in Neurosciences·D Wigston
Oct 1, 1994·Brain Research. Molecular Brain Research·S P Jayawickreme, T Claudio
Sep 4, 2010·The Journal of Biological Chemistry·Pessah YampolskyVeit Witzemann
Jul 26, 2011·Brain : a Journal of Neurology·Vicki AndersonAmanda Wood
Jun 21, 1993·Annals of the New York Academy of Sciences·M M SalpeterT Lomo
Mar 20, 2014·The Journal of Clinical Investigation·Mitra LavasaniJohnny Huard
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·G BezakovaT Lømo
Jun 1, 1992·Neuropathology and Applied Neurobiology·P SerdarogluW K Engel
Jul 14, 1997·The Journal of Cell Biology·J P O'MalleyM M Salpeter
Nov 20, 2004·The Journal of Physiology·Othon L Gervásio, William D Phillips
Oct 1, 1995·Journal of Cellular Physiology·R Xu, M M Salpeter
Oct 7, 2015·Progress in Neurobiology·Clarke R Slater
Mar 28, 2012·Journal of Cachexia, Sarcopenia and Muscle·Elisabetta FerraroLibera Berghella
Aug 15, 2006·Neurochemistry International·Sergey N GrishinAndrás Palotás
Jan 1, 1997·Molecular and Cellular Neurosciences·W D PhillipsP G Noakes
Oct 20, 2017·International Journal of Molecular Sciences·Clarke R Slater
Aug 14, 2019·Muscle & Nerve·Bianca VannucciAlison K Snyder-Warwick

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