Degradation studies of modified inulin as potential encapsulation material for colon targeting and release of mesalamine

Carbohydrate Polymers
Michael WalzThomas Henle

Abstract

Due to the potential to treat colon specific diseases with reduced side effects, colon targeting has become of high interest over the last decades. Chemical modified inulin was investigated for its potential as encapsulation material regarding its enzymatic degradability and its drug release behavior. Different degrees of acetylated inulin (degree of substitution, DS, 0.3-2.1) were synthesized. The chemical modification leads to a reduction in enzymatic degradability by inulinase and esterase, enzymes which can be expressed by the colon microbiota. Acetylated inulin was only hydrolyzed to fructose units up to DS of 1.3. Microparticles made of native inulin and acetylated inulin (DS 1.8) were loaded with the colon-specific drug mesalamine by spray drying. Compared to the burst release of mesalamine by inulin particles within 6 h, acetylated inulin particles showed less burst release followed by a continuous drug release phase caused by diffusion up to 30% mesalamine after 52 h.

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Citations

Apr 10, 2019·Polymers·Yuan ChenZhanyong Guo
Dec 2, 2020·Critical Reviews in Analytical Chemistry·Alberto Gomes Tavares JuniorMarlus Chorilli
Nov 5, 2019·Advances in Colloid and Interface Science·Adi SeifertYoav D Livney
Jun 21, 2021·International Journal of Pharmaceutics·Surajit Das
Jul 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pedro M VelosoClarisse Nobre

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