Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Itsuro MatsumotoT Aikawa

Abstract

The effect of intracerebroventricular infusion of compound 48/80 (C48/80), a mast cell secretagogue, on adrenal cortisol secretion was investigated in dogs under pentobarbital sodium anesthesia. A marked increase in adrenal cortisol secretion was elicited by C48/80 along with a concomitant increase in the plasma levels of cortisol and immunoreactive ACTH, but neither arterial blood pressure and heart rate nor the plasma histamine level altered significantly. Pretreatment with either anti-CRF antiserum or pyrilamine maleate (H(1) histamine-receptor antagonist) significantly attenuated the C48/80-evoked increase in cortisol secretion, but pretreatment with metiamide (H(2)-receptor antagonist) significantly potentiated it. Significant attenuation of the C48/80-evoked increase in cortisol also occurred in dogs given ketotifen, a mast cell stabilizing drug, before pharmacologic challenge. In the pars tuberalis and median eminence (ME), mast cells were highly concentrated in close association with the primary plexus of the hypophysial portal system. Degranulated mast cells were extensively found in the ME of C48/80-treated animals. These results suggest that mast cells located in these regions liberated histamine within the brain as ...Continue Reading

References

Nov 1, 1975·European Journal of Pharmacology·M VerdiereJ C Schwartz
Oct 1, 1978·Physiological Reviews·R I Weiner, W F Ganong
Jan 1, 1979·Neuroendocrinology·C RudolphW F Ganong
Jan 1, 1979·Acta Anatomica·J J Dropp
Sep 1, 1992·Neurochemical Research·D Johnson, W Krenger
Jan 1, 1992·The American Journal of Physiology·A M Reynier-RebuffelP Aubineau
Jan 1, 1991·Physiological Reviews·J C SchwartzM Ruat
Nov 1, 1986·The American Journal of Physiology·K KogureM Suzuki
Jan 1, 1989·International Archives of Allergy and Applied Immunology·W M PurcellT H Hanahoe
Dec 1, 1986·The American Journal of Physiology·M P LillyD S Gann
Nov 1, 1986·The American Journal of Physiology·E M WagnerE R Bleecker
Apr 1, 1985·Journal of Applied Physiology·K F ChungW M Gold
Jun 1, 1985·Journal of Neurochemistry·R C GoldschmidtS D Glick
Apr 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U Martin, M Baggiolini
Apr 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·H RaffM F Dallman
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P PanulaE Costa
Jun 1, 1994·Agents and Actions·A J BugajskiJ Bugajski
Jun 1, 1994·Agents and Actions·G Zwadlo-KlarwasserW Schmutzler
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Jun 1, 1994·The American Journal of Physiology·M P Lilly
Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A J BugajskiJ Bugajski
May 2, 1996·Nature·S J Galli, B K Wershil
Feb 1, 1996·Endocrine Reviews·H O Besedovsky, A del Rey
Jan 1, 1996·Trends in Neurosciences·R SilverI I Lederhendler
Sep 1, 1996·The American Journal of Physiology·L E MorrowM J Kluger
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori

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Citations

Jan 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Itsuro MatsumotoTadaomi Aikawa

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