Degree of dopaminergic degeneration measured by 99m Tc-TRODAT-1 SPECT/CT imaging

Neural Regeneration Research
Ling LinZhi-Hong Zheng

Abstract

To prevent and treat Parkinson's disease in its early stages, it is essential to be able to detect the degree of early dopaminergic neuron degeneration. Dopamine transporters (DAT) in the striatum regulate synaptic dopamine levels, and striatal 99mTc-TRODAT-1 single-photon emission computed tomography (-SPECT) imaging is a marker for presynaptic neuronal degeneration. However, the association between the degree of dopaminergic degeneration and in vivo 99mTc-TRODAT-1 SPECT imaging is unknown. Therefore, this study investigated the association between the degree of 6-hydroxydopamine (6-OHDA)-induced dopaminergic degeneration and DAT imaging using 99mTc-TRODAT-1 SPECT in rats. Different degrees of nigrostriatal dopamine depletion were generated by injecting different doses of 6-OHDA (2, 4, and 8 μg) into the right medial forebrain bundle. The degree of nigrostriatal dopaminergic neuron degeneration was assessed by rotational behavior and immunohistochemical staining. The results showed that striatal 99mTc-TRODAT-1 binding was significantly diminished both in the ipsilateral and the contralateral sides in the 4 and 8 μg 6-OHDA groups, and that DAT 99mTc-TRODAT-1 binding in the ipsilateral striatum showed a high correlation to apomo...Continue Reading

References

Jul 19, 2005·British Journal of Pharmacology·Vincent Seutin
Jul 7, 2006·Cellular and Molecular Neurobiology·Toshi Nagatsu, Makoto Sawada
Mar 7, 2007·British Journal of Pharmacology·P S Whitton
Dec 22, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Georg GoebelChristoph Scherfler
Dec 24, 2010·Journal of Visualized Experiments : JoVE·Oscar Gonzalez-PerezAlfredo Quiñones-Hinojosa
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·A Jon Stoessl
Feb 10, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Hao WuGuohua Shi
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Aug 4, 2011·Brain : a Journal of Neurology·Jeffrey L CummingsPaul Kemp
Apr 25, 2012·Journal of Biomedicine & Biotechnology·Ling WangHong Zhang
Apr 27, 2012·Journal of Biomedicine & Biotechnology·Javier BlesaSerge Przedborski
May 10, 2012·Journal of Biomedicine & Biotechnology·Lie-Hang ShenYu-Chin Tseng
Oct 26, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Weidong LeJoseph Jankovic
Jun 4, 2014·Contrast Media & Molecular Imaging·Aida Niñerola-BaizánDomènec Ros
Jun 7, 2014·AJNR. American Journal of Neuroradiology·T C BoothJ Buscombe
Jun 24, 2014·Lancet·A Jon StoesslAntonio P Strafella
Jul 23, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Julia KraemmerWalter Pirker
Aug 12, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Edson Bor-Seng-ShuHenrique Ballalai Ferraz
Dec 10, 2014·Parkinsonism & Related Disorders·Fang Ba, W R Wayne Martin
Jan 28, 2015·Nuclear Medicine and Biology·Aida Niñerola-BaizánJavier Pavía
May 9, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Juho JoutsaValtteri Kaasinen
Nov 28, 2015·Neuropathology and Applied Neurobiology·Arianna BellucciPierFranco Spano
Aug 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Gennaro PaganoMarios Politis
May 23, 2017·NeuroImage. Clinical·Thomas R BarberMichele T M Hu
Aug 2, 2017·Neural Regeneration Research·Juan Segura-Aguilar

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

TomoTM
Tera
SPSS
[UNK]
DaT

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.