Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature.

Scientific Reports
Kiyonobu IshizukaMotoshi Hattori

Abstract

Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from secondary FSGS. However, no systematic evaluation of FPE in genetic FSGS has been performed. In this study, percentage of FPE and foot process width (FPW) in native kidney biopsies were analyzed in eight genetic FSGS patients and nine primary FSGS patients. All genetic FSGS patients showed segmental FPE up to 38% and FPW below 2000 nm, while all primary FSGS patients showed diffuse FPE above 88% and FPW above 3000 nm. We reviewed the literature which described the degree of FPE in genetic FSGS patients and identified 38 patients with a description of the degree of FPE. The degree of FPE in patients with mutations in the genes encoding proteins associated with slit diaphragm and cytoskeletal proteins was varied, while almost all patients with mutations in other FSGS genes showed segmental FPE. In conclusion, the present study suggests that the degree of FPE in native kidney biopsies may be useful for differentiating some genetic FSGS patients...Continue Reading

References

Oct 3, 1999·Journal of the American Society of Nephrology : JASN·E DenamurP M Ronco
Apr 11, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kyoko MaruyamaNorishige Yoshikawa
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Klaas KoopJan A Bruijn
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vivette D D'AgatiJ Charles Jennette
Aug 19, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jianguo LiHongwen Zhang
Oct 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Martin R PollakJoel M Henderson
Oct 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannu Jalanko
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Bernward HinkesUNKNOWN APN Study Group
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HattoriH Tsukaguchi
Sep 25, 2008·Kidney International·Jeroen K J DeegensJack F M Wetzels
Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Joel M HendersonMartin R Pollak
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Dec 22, 2009·Nature Genetics·Elizabeth J BrownMartin R Pollak
Feb 13, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Elisa BenettiLuisa Murer
Aug 31, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyun Kyung LeeHae Il Cheong
Mar 24, 2011·Clinical Nephrology·V LiakopoulosG B Appel
Dec 23, 2011·The New England Journal of Medicine·Vivette D D'AgatiRonald J Falk
Nov 2, 2012·The Journal of Clinical Investigation·Nayia NicolaouArnoud Sonnenberg
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Jan 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julia M HofstraTom Nijenhuis
Jan 17, 2013·Nature Reviews. Nephrology·Rasheed A GbadegesinWilliam E Smoyer
Mar 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sanjeev SethiFernando C Fervenza
Jun 28, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Elisa BenettiLuisa Murer
Sep 18, 2014·Kidney International·Andrew F MaloneRasheed A Gbadegesin
Oct 29, 2014·Journal of the American Society of Nephrology : JASN·Carolin E SadowskiFriedhelm Hildebrandt
Dec 17, 2014·Clinical Kidney Journal·Sanjeev SethiFernando C Fervenza
Feb 16, 2016·Nature Genetics·Daniela A BraunFriedhelm Hildebrandt
Aug 19, 2016·Nature·Monkol LekUNKNOWN Exome Aggregation Consortium
Dec 13, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomohiro UdagawaYutaka Harita
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ladan ZandFernando C Fervenza
Nov 29, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rebecca PrestonRachel Lennon
Jan 13, 2018·Journal of the American Society of Nephrology : JASN·An S De VrieseFernando C Fervenza
Apr 13, 2018·Clinical Kidney Journal·Nicola LeporiFernando C Fervenza
Sep 2, 2019·Kidney International·Ashish K SolankiDeepak Nihalani

❮ Previous
Next ❯

Software Mentioned

ImageJ
PolyPhen
Burrows Aligner

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Netherlands Journal of Medicine
J K J DeegensJack F M Wetzels
Clinical Journal of the American Society of Nephrology : CJASN
Avi Z Rosenberg, Jeffrey B Kopp
© 2021 Meta ULC. All rights reserved