Degree of hyperinsulinemia, independent of androgen levels, is an important determinant of the severity of hirsutism in PCOS.

Fertility and Sterility
Melanie LandayRicardo Azziz

Abstract

To determine whether the severity in hyperandrogenemia determines, to a significant degree, the severity of hirsutism in patients with polycystic ovary syndrome (PCOS). Cross-sectional study. Tertiary care academic referral center. A total of 749 patients with PCOS. History and physical examination, blood sampling. Hirsutism defined by a value of >or=6 using the modified Ferriman-Gallwey (mFG) score, age, body mass index (BMI), calculated homeostatic assessment for insulin resistance (HOMA-IR) value, and levels of total (TT) and free (FT) testosterone, dehydroepiandrosterone sulfate (DHEAS) 17-hydroxyprogesterone (17OH-P), and fasting insulin (INS) and glucose (GLC). Univariate correlations revealed associations between the mFG score and INS, 17OH-P, HOMA-IR, and BMI. Multivariate classification and regression tree analysis indicated that INS had the most significant association with mFG score and that at higher INS levels T played an additional role whereas at lower INS levels 17OH-P had an effect; however, this model accounted for only 8.2% of total variation in mFG score. Insulin appears to have a direct effect on the severity of hirsutism in PCOS and appears to have a synergistic interaction with TT. Notably, over 90% of th...Continue Reading

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Citations

Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Mary E RauschUNKNOWN Reproductive Medicine Network
Apr 6, 2013·European Journal of Endocrinology·Dimitrios PanidisIlias Katsikis
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Jul 31, 2012·Journal of Pediatric and Adolescent Gynecology·Maude Veilleux-Lemieux, Amy Desrochers DiVasta
Jul 9, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Daria LiznevaRicardo Azziz
Oct 28, 2016·Journal of Endocrinological Investigation·M A PappalardoS Benvenga
Dec 15, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Linxia LiXiaoying Ding
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May 20, 2017·International Journal of Clinical Practice·Vasilios PergialiotisNikolaos Papantoniou
Jan 20, 2018·American Journal of Physiology. Endocrinology and Metabolism·Stanley AndrisseSheng Wu
Jul 12, 2018·Obstetrics and Gynecology·Ricardo Azziz
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Jul 23, 2020·Clinical Obstetrics and Gynecology·Karine Matevossian, Olivia Carpinello

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