Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

International Journal of Biological Sciences
Zhang BaoJianying Zhou

Abstract

Asthma is a chronic respiratory disease characterized by airway inflammation and remodeling, resulting in a substantial economic burden on both patients and society. Deguelin, a constituent of theLeguminosaefamily, exhibits anti-proliferative and anti-inflammatory activities in cancer mice models via inhibiting phosphatidylinositol 3-kinases and the NF-κB pathway. We demonstrated that deguelin effectively reduced OVA-induced inflammatory cell recruitment, decreased lung tissue inflammation and mucus production, suppressed airway hyperresponsiveness, and inhibited serum immunoglobulin and Th2 cytokine levels in a dose-dependent manner in asthmatic mice. In addition, we found that deguelin reduced inflammatory gene expressions bothin vivoandin vitro, which were closely associated with activation of the NF-κB signaling pathway. Thus, we further explored the underlying mechanisms of deguelin in normal human bronchial epithelial cells (BEAS-2B). Our results suggested that deguelin inhibited NF-κB binding activity by enhancing the ability of IκBα to maintain NF-κB in an inactive form in the cytoplasm and preventing the TNF-α induced translocation of p65 to the nucleus. In conclusion, our research indicates that deguelin attenuates al...Continue Reading

Citations

Feb 6, 2020·Experimental and Therapeutic Medicine·Pingping FengHongbo Shen
Sep 1, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaojie RenYong Wang
Apr 18, 2019·International Journal of Molecular Sciences·Na-Rae ShinJoong-Sun Kim
Feb 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hardeep Singh TuliAnupam Bishayee
Jan 24, 2020·European Journal of Medicinal Chemistry·Thadeu E M M CostaCarmen Penido
Jul 16, 2019·International Immunopharmacology·Jéssica Vieira CerqueiraMilena Botelho Pereira Soares

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Methods Mentioned

BETA
nuclear translocation
ELISA
PCR
protein assay
flow cytometry

Software Mentioned

CellQuest
Quantity One
SPSS

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