Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy.

Journal of Cellular and Molecular Medicine
J H KimK-W Kim

Abstract

Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic retinopathy for young age group. ROP still remains as the most serious cause of vision loss in children. We provided that deguelin significantly reduces retinal neovascularization in a mouse model of ROP. Deguelin never affected the transcriptional activity of hypoxia inducible factor (HIF)-1, however, reduced HIF-1 expression, which led to the decrease of vascular endothelial growth factor expression. Deguelin effectively suppressed endothelial cell proliferation without cytotoxic effect under therapeutic concentration range. In addition, deguelin demonstrated no reduction or retardation in normal retinal development and no retinal toxicity. These data suggest deguelin is a potent inhibitor of retinal neovascularization and may be applied in the treatment of other vasoproliferative retinopathies.

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Citations

Nov 6, 2010·Archives of Pharmacal Research·Dong Hyun JoJeong Hun Kim
Sep 17, 2009·Antioxidants & Redox Signaling·Simon NagelChristopher J Schofield
Jun 22, 2013·Journal of Biomedical Science·Dong Hyun JoJeong Hun Kim
May 31, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dong Hyun JoJeong Hun Kim
Oct 12, 2014·Experimental Eye Research·Rania S SulaimanTimothy W Corson
Aug 26, 2009·Biochimie·Bogdan ManolescuCornelia Cercasov
Jul 11, 2009·Vascular Pharmacology·Jeong Hun KimKyu-Won Kim
Nov 30, 2013·Scientific Reports·Mariko KyutokuRyuichi Morishita
May 30, 2017·Expert Opinion on Therapeutic Targets·Shi-Yang GuanHai-Feng Pan
Feb 19, 2014·Journal of Cellular and Molecular Medicine·Sung Wook ParkJeong Hun Kim
Aug 24, 2017·Journal of Neuroinflammation·José Carlos RiveraSylvain Chemtob
May 6, 2015·Chemical Communications : Chem Comm·Seungbeom LeeYoung-Ger Suh
Apr 17, 2019·Nutrients·Maria Grazia Rossino, Giovanni Casini
Apr 27, 2013·Acta Ophthalmologica·Giacomo CavallaroFabio Mosca
Sep 6, 2019·International Journal of Molecular Sciences·Jessica K W TsangAmy C Y Lo
Jul 29, 2010·The Journal of Pharmacy and Pharmacology·Soumyajit Majumdar, Ramesh Srirangam
Jun 10, 2011·Free Radical Research·Bokyung SungBharat B Aggarwal
Jun 1, 2016·Assay and Drug Development Technologies·Hermann A M Mucke
Jan 1, 2010·Expert Review of Endocrinology & Metabolism·Jason P GlotzbachGeoffrey C Gurtner
Jan 28, 2021·Life·Jessica K W TsangAmy C Y Lo
Sep 12, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sk Abdul AminTarun Jha
Mar 19, 2021·Ocular Immunology and Inflammation·Alireza ShahriaryHossein Aghamollaei
May 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hui-Yao LiXin-Yuan Gao

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Methods Mentioned

BETA
light microscopy
transfection
protein assay

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