Dehydrated human amnion/chorion tissue in difficult-to-heal DFUs: a case series

Journal of Wound Care
H PennyR Flores

Abstract

Diabetic foot ulcers (DFUs) occur as a result of multifactorial complications and are commonly found in the diabetic community. Underlying disease states such as neuropathy and peripheral vascular disease can slow healing rates, potentially leading to recurrence, amputation, and increased mortality. As with many other disease processes, DFUs have several treatment options, such as debriding agents, alginate seaweed extract, hydrocolloid gels, and amniotic membrane allografts. The presented cases all used a dehydrated human amniotic/chorionic membrane allograft (dHACM; EpiFix) to aid the healing process. Human amniotic epithelial membranes have seen increased usage due to their ability to enhance the healing process and accelerate cellular regeneration. The DFUs healed in all of the five patients treated, and patients saw a full recovery in 2.5-11 weeks. In addition, the healing time decreased in spite of the non-adherence seen in three of the patients. These results suggest another possible use for dHACM; however, further studies are required to confirm these data. This project was self-funded and had no influences outside the fact that Dr Penny is a speaker for MiMedx.

References

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Citations

Aug 30, 2018·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·André Oliveira PaggiaroRolf Gemperli
Feb 9, 2018·Journal of Wound Care·André Oliveira PaggiaroRolf Gemperli
Sep 12, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert S KirsnerJohn C Lantis
Apr 20, 2021·Journal of the American Podiatric Medical Association·Andrew S AuJames W Stavosky

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Methods Mentioned

BETA
amputations
amputation

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