Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs.

American Journal of Physiology. Renal Physiology
Erin BaggaleyD Marples

Abstract

It is now well established that the antidiuretic response to vasopressin is modulated by changes in aquaporin-2 (AQP2) expression in response to hydration status. While vasopressin itself is one signal driving expression, other signals also play a part. In this study, we planned to investigate whether prostaglandins, known to modulate AQP2 trafficking, may play a role in this process. Male Wistar rats were kept in metabolic cages, with either free access to water and food, or were given 15 g of food gelled with water, such that they were fluid restricted or fluid loaded. The effects of oral administration of two structurally different NSAIDs, indomethacin and ibuprofen, and a COX-2-selective NSAID, meloxicam, on urine output and AQP2 expression were investigated in kidneys removed under terminal anesthesia. All the NSAIDs decreased AQP2 expression significantly in water-restricted rats but did not significantly alter PGE excretion. In water-loaded rats, the effects were less marked, and meloxicam had no significant effect. Consistent with this, ibuprofen prevented the increase in AQP2 expression seen in response to dehydration. These results demonstrate that NSAIDs decrease AQP2 protein abundance, particularly during adaptation...Continue Reading

References

Jul 1, 1976·Acta Physiologica Scandinavica·U B OlsenE Eilertsen
Aug 1, 1992·The American Journal of Physiology·W L Smith
Sep 1, 1991·The American Journal of Physiology·S P LankfordM A Knepper
Jun 1, 1988·The American Journal of Physiology·M SugawaraZ Ota
Jun 1, 1985·The Journal of Clinical Investigation·S ChristensenT P Dousa
Jan 1, 1986·The American Journal of Physiology·S P NadlerB M Brenner
Jul 1, 1983·Clinical Science·H G GüllnerM D Mitchell
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·S R DiGiovanniM A Knepper
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y AsahinaC Sato
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NielsenM A Knepper
Apr 1, 1995·The Journal of Clinical Investigation·D MarplesS Nielsen
Dec 1, 1994·The Journal of Clinical Investigation·R C HarrisM D Breyer
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S NielsenH W Harris
Aug 1, 1996·The American Journal of Physiology·J TerrisM A Knepper
Jan 1, 1997·Journal of the American Society of Nephrology : JASN·E ApostolM A Knepper
Apr 15, 1997·The Journal of Clinical Investigation·C A EcelbargerJ G Verbalis
Apr 1, 1997·The Journal of Clinical Investigation·D L XuR W Schrier
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NielsenJ S Petersen
Apr 16, 1998·The Journal of Clinical Investigation·M OharaR W Schrier
Dec 5, 1998·The American Journal of Physiology·C A EcelbargerM A Knepper
Dec 16, 1998·Journal of the American Society of Nephrology : JASN·J H EarmS Nielsen
Jul 17, 1999·The American Journal of Physiology·T YangJ P Briggs
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takashi MuraseJoseph G Verbalis
May 1, 1957·The Journal of Clinical Investigation·F H EPSTEINA HENDRIKX
Nov 14, 1957·The Journal of Physiology·H E DE WARDENER, A HERXHEIMER
Oct 15, 2003·Archives of Surgery·Andrew E Luckey, Cyrus J Parsa
Jan 27, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Keizo KasonoSan-e Ishikawa
Apr 22, 2005·Journal of the American Society of Nephrology : JASN·Udo HaslerEric Féraille
Aug 21, 2009·American Journal of Physiology. Renal Physiology·Zhanjun JiaTianxin Yang

❮ Previous
Next ❯

Citations

Jul 21, 2010·Pharmaceuticals·Walter H Hörl
Jan 19, 2012·Molecular Aspects of Medicine·Ross P Holmes
Mar 24, 2016·Journal of the American Society of Nephrology : JASN·Fei WangTianxin Yang
Apr 22, 2016·Journal of the American Society of Nephrology : JASN·Boye L Jensen
Dec 1, 2017·International Journal of Molecular Sciences·Yuyuan LiXiaoyan Zhang
Nov 20, 2012·Journal of the American Society of Nephrology : JASN·Emma T B Olesen, Robert A Fenton
Sep 2, 2011·American Journal of Physiology. Renal Physiology·Rikke NørregaardBoye L Jensen
Oct 31, 2015·PloS One·Huiwen RenJanet D Klein
Jun 25, 2014·Toxicology and Industrial Health·Dilek BurukogluEzgi Bektur
Aug 3, 2019·International Journal of Environmental Research and Public Health·Sarath GunatilakeLaura Orlando

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.