Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function.

Physiological Reports
Kazuhito WatanabeJosé González-Alonso

Abstract

Dehydration accrued during intense prolonged whole-body exercise in the heat compromises peripheral blood flow and cardiac output ( Q ˙ ). A markedly reduced stroke volume (SV) is a key feature of the dehydration-induced cardiovascular strain, but whether the lower output of the heart is mediated by peripheral or cardiac factors remains unknown. Therefore, we repeatedly quantified left ventricular (LV) volumes, LV mechanics (LV twist, a marker of systolic muscle function, and LV untwisting rate, an independent marker of LV muscle relaxation), left intra-ventricular pressure gradients, blood volume and peripheral blood flow during 2 hr of cycling in the heat with and without dehydration (DEH: 4.0 ± 0.2% body mass loss and EUH: euhydration control, respectively) in eight participants (three females and five males). While brachial and carotid blood flow, blood volume, SV, LV end-diastolic volume (LVEDV), cardiac filling time, systemic vascular conductance and Q ˙ were reduced in DEH compared to EUH after 2 hr, LV twist and untwisting rate tended to be higher (p = .09 and .06, respectively) and intra-ventricular pressure gradients were not different between the two conditions (p = .22). Furthermore, LVEDV in DEH correlated strong...Continue Reading

References

Jul 1, 1979·Circulation·J O Parker, R B Case
Nov 1, 1977·The American Journal of Cardiology·K SagawaK M Bakalar
Sep 1, 1992·Journal of Applied Physiology·S J Montain, E F Coyle
Oct 1, 1992·Journal of Applied Physiology·S J Montain, E F Coyle
Sep 1, 1991·Journal of Applied Physiology·M T HamiltonE F Coyle
Sep 1, 1990·Journal of Applied Physiology·B NielsenB Saltin
Dec 1, 1987·Circulation·P S DouglasN Reichek
Aug 1, 1974·Journal of Applied Physiology·D B Dill, D L Costill
Feb 1, 1971·Circulation·J O ParkerR B Case
May 1, 1965·Journal of Applied Physiology·L B RowellR A Bruce
Oct 12, 1967·The New England Journal of Medicine·A C Guyton
Nov 1, 1983·The American Journal of Physiology·K SunagawaK Sagawa
Apr 1, 1997·Journal of Applied Physiology·J González-AlonsoE F Coyle
Apr 30, 1998·International Journal of Sports Medicine·S J MontainC R Valeri
Aug 7, 1998·International Journal of Sports Medicine·J González-Alonso
Nov 24, 1998·The Journal of Physiology·J González-AlonsoB Nielsen
Mar 6, 1999·Journal of Applied Physiology·R G FritzscheE F Coyle
Aug 11, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M AlamR Nordlander
Aug 13, 1999·The American Journal of Physiology·J González-AlonsoE F Coyle
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J González-AlonsoE F Coyle
Jun 22, 2000·Medicine and Science in Sports and Exercise·G P WhyteW J McKenna
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·N L GreenbergJ D Thomas
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Aleksandr RovnerMario J Garcia
May 1, 1964·Journal of Applied Physiology·N L RAMANATHAN
May 25, 2004·The Journal of Physiology·Jaya B RosenmeierJosé González-Alonso
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J A L CalbetR Boushel
Sep 8, 1914·The Journal of Physiology·S W Patterson, E H Starling
Oct 8, 2009·Circulation. Cardiovascular Imaging·Stéphane NottinPhilippe Obert
Jul 3, 2010·Journal of Applied Physiology·Joel D TrinityEdward F Coyle
Jul 6, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·David OxboroughKeith George
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Eric J StöhrRob Shave
May 24, 2011·European Journal of Applied Physiology·Stéphane NottinNicolas Tordi

❮ Previous
Next ❯

Citations

Sep 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Gavin TraversJulien D Periard
Oct 20, 2020·Frontiers in Physiology·Alexandra M CoatesJamie F Burr

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics
LabChart
EchoPAC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.