Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

Burns and Trauma
Conor BentleyMark Foster

Abstract

Severe injuries are the major cause of death in those aged under 40, mainly due to road traffic collisions. Endocrine, metabolic and immune pathways respond to limit the tissue damage sustained and initiate wound healing, repair and regeneration mechanisms. However, depending on age and sex, the response to injury and patient prognosis differ significantly. Glucocorticoids are catabolic and immunosuppressive and are produced as part of the stress response to injury leading to an intra-adrenal shift in steroid biosynthesis at the expense of the anabolic and immune enhancing steroid hormone dehydroepiandrosterone (DHEA) and its sulphated metabolite dehydroepiandrosterone sulphate (DHEAS). The balance of these steroids after injury appears to influence outcomes in injured humans, with high cortisol: DHEAS ratio associated with increased morbidity and mortality. Animal models of trauma, sepsis, wound healing, neuroprotection and burns have all shown a reduction in pro-inflammatory cytokines, improved survival and increased resistance to pathological challenges with DHEA supplementation. Human supplementation studies, which have focused on post-menopausal females, older adults, or adrenal insufficiency have shown that restoring the ...Continue Reading

References

Jan 31, 1975·Nature·M JohnsonP W Ramwell
Oct 1, 1992·The Journal of Clinical Endocrinology and Metabolism·N OrentreichH Baldwin
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·L N ParkerE T Lifrak
Oct 1, 1995·Clinical Endocrinology·G Van den BergheP Lauwers
Aug 1, 1995·The Journal of Surgical Research·B A AraneoR A Daynes
Dec 29, 1995·Annals of the New York Academy of Sciences·S S YenO Khorram
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·F LabrieB Candas
Jul 2, 1998·Proceedings of the Society for Experimental Biology and Medicine·F Svec, J R Porter
Feb 5, 2000·The Journal of Endocrinology·M SchmidtR H Straub
Nov 18, 2000·Pharmacotherapy·J M GervasioR O Brown
Nov 18, 2000·Biological Psychiatry·A MichaelJ Herbert
Apr 5, 2001·Trends in Molecular Medicine·D JarrarI H Chaudry
Nov 27, 2001·European Journal of Endocrinology·B Stoffel-Wagner
May 17, 2002·International Journal of Colorectal Disease·Miklós SzathmáriZsolt Tulassay
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·William E RaineyJ Ian Mason
Aug 16, 2002·World Journal of Surgery·Alvaro OsorioEstrella Ruiz-Requena
Oct 26, 2002·Critical Care : the Official Journal of the Critical Care Forum·Albertus BeishuizenIstván Vermes
Jan 29, 2003·Intensive Care Medicine·A PernerJ Rask-Madsen
Apr 15, 2003·Journal of Applied Physiology·Markus W KnoferlIrshad H Chaudry
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masatoshi SuzukiClive N Svendsen
Apr 17, 2004·Shock·Christopher J GannonLena M Napolitano
Apr 21, 2004·Circulation·Majon MullerYvonne T van der Schouw
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Dennis T Villareal, John O Holloszy

❮ Previous
Next ❯

Citations

Jul 16, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nadezhda D Goncharova
Jul 28, 2020·Journal of Clinical Medicine·Philipp KobbeFrank Hildebrand
Sep 16, 2021·Endocrine Regulations·Sojit TomoMahendra Garg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.