Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders

Journal of Clinical Medicine
Chia-Jung LiKuan-Hao Tsui

Abstract

Mitochondrial dysfunction is related to reproductive decline in humans, with consequences for in vitro fertilization (IVF). We assessed whether dehydroepiandrosterone (DHEA) could regulate mitochondrial homeostasis and mitophagy of cumulus cells (CCs) in poor ovarian responders (PORs). A total of 66 women who underwent IVF treatment at the Reproductive Medicine Center of Kaohsiung Veterans General Hospital were included in this study. Twenty-eight normal ovarian responders (NOR) and 38 PORs were enrolled. PORs were assigned to receive DHEA supplementation (n = 19) or not (n = 19) before IVF cycles. DHEA prevents mitochondrial dysfunction by decreasing the activation of DNM1L and MFF, and increasing MFN1 expression. Downregulation of PINK1 and PRKN occurred after DHEA treatment, along with increased lysosome formation. DHEA not only promoted mitochondrial mass but also improved mitochondrial homeostasis and dynamics in the CCs of POR. We also observed effects of alterations in mRNAs known to regulate mitochondrial dynamics and mitophagy in the CCs of POR. DHEA may prevent mitochondrial dysfunction through regulating mitochondrial homeostasis and mitophagy.

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Citations

Apr 5, 2019·Journal of the Chinese Medical Association : JCMA·Yau-Hong LiPeng-Hui Wang
Jan 2, 2020·Antioxidants & Redox Signaling·Alexandra E PetersJessie M Sutherland
Oct 21, 2020·Biology of Reproduction·Qiuzi ShenLing Zhang
Jan 6, 2021·Biomolecules·An-Jen ChiangJim Jinn-Chyuan Sheu
Nov 27, 2019·JAAPA : Official Journal of the American Academy of Physician Assistants·Shilpa N GajarawalaAmanda P Stanton

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NCT03438812

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