PMID: 15374110May 1, 1997Paper

Dehydroepiandrosterone (DHEA) and aging

Archives of Gerontology and Geriatrics
Z BarrouC Lidy

Abstract

Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid hormone in humans and can readily be converted to its parent steroid DHEA by tissue sulfatases. Yet, a biologic function for these steroids has not been defined. The link between DHEA and aging has been raised by: (1) its well documented age-related decline, and (2) a preventive effect of DHEA on numerous age-related illnesses: ischemic heart-disease, cognitive impairment, immunodeficiency, malignancies, osteoporosis. These effects have been suggested by epidemiological studies in humans. Animal studies support a protective effect of DHEA on these age-related diseases. However, it remains unknown whether these results in animals can be transposed in humans, because adrenal secretion of DHEA seems to be particular to primates. In humans, only a few studies have been performed. The effects of oral supplementation with DHEA have, so far, focused on the possible metabolic effects of DHEA. A few studies have shown: the absence of any side-effects; no change in body-weight; conflicting results on body-composition and lipids and no effect on insulin-tolerance. The latest study showed a beneficial effect on well-being but these results need to be confirmed.

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Citations

Oct 26, 2006·Aging Clinical and Experimental Research·UNKNOWN GISEG (Italian Study Group on Geriatric Endocrinology)Maurizio Latini
Apr 3, 2001·Physiology & Behavior·M MarkowskiC Locurto
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Feb 28, 2002·Journal of Clinical Pharmacology·Firoozeh S SalekPatricia Dowley Kroboth
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S S Yen
Jan 1, 1997·Aging : Clinical and Experimental Research·G Valenti
May 6, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Marcello MaggioGian Paolo Ceda
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Jul 16, 2005·Experimental Gerontology·Martine Perret, Fabienne Aujard
Oct 16, 2002·Journal of Pharmaceutical Sciences·Gian Carlo CeschelCelestino Ronchi
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Miroslav RypkaJaroslav Veselý
Jan 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Athanasios ZiogasVasileia Ismini Alexaki

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