PMID: 8597466Dec 29, 1995Paper

Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo

Annals of the New York Academy of Sciences
R L JesseJ E Nestler

Abstract

The hypothesis has been advanced that the adrenal steroids dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert antiatherogenic and cardioprotective actions. Platelet activation has also been implicated in atherogenesis. To determine if DHEA and DHEAS affect platelet activation, the effects of these steroids on platelet aggregation were assessed both in vitro and in vivo. When DHEAS was added to pooled platelet-rich plasma before the addition of the agonist arachidonate, either the rate of platelet aggregation was slowed or aggregation was completely inhibited. Inhibition of platelet aggregation by DHEA was both dose- and time-dependent. Inhibition of platelet aggregation by DHEA was accompanied by reduced platelet thromboxane B2 (TxB2) production. Inhibition of platelet aggregation by DHEA was also demonstrated in vivo. In a randomized, double-blind trial, 10 normal men received either DHEA 300 mg (n = 5) or placebo capsule (n = 5) orally three times daily for 14 days. In one man in the DHEA group arachidonate-stimulated platelet aggregation was inhibited completely during DHEA administration, whereas in three other men in the DHEA group the rate of platelet aggregation was prolonged, and the sensitivity and responsive...Continue Reading

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Citations

Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·W PengI S Farrukh
Apr 18, 2003·Endocrine Reviews·Fredrick C W Wu, Arnold von Eckardstein
Jun 8, 2012·Physiological Research·A GarridoL Valladares
Jul 7, 2001·American Journal of Therapeutics·R J Gaytan, L M Prisant
Oct 25, 2002·Cardiovascular Drug Reviews·Wolfgang Weidemann, Hartmut Hanke
Jan 1, 1997·Aging : Clinical and Experimental Research·G Valenti
Feb 24, 2001·Menopause : the Journal of the North American Menopause Society·G P BerniniA Salvetti
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·G P BerniniA Salvetti
May 14, 1998·The Journal of Laboratory and Clinical Medicine·D M Herrington
May 16, 2006·Journal of Molecular and Cellular Cardiology·Eric D MorrellDaniel R Meldrum

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