PMID: 7542411May 1, 1995Paper

Dehydroepiandrosterone inhibits replication of feline immunodeficiency virus in chronically infected cells

Veterinary Immunology and Immunopathology
W G BradleyN K Day

Abstract

Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal cortex that serves as an intermediary in sex steroid synthesis. DHEA is produced in abundance by humans and most other warm-blooded animals. Based upon previous reports demonstrating the antiviral and immunostimulatory activities of DHEA and DHEA-sulfate (DHEAS) we sought to determine whether introduction of these compounds would affect replication of feline immunodeficiency virus (FIV) in chronically infected cells. When cell number, cell viability, cellular DNA synthesis, and levels of FIV reverse-transcriptase (RT) were measured in cell cultures treated with various dilutions of DHEA or DHEAS it was found that the production of FIV RT was inhibited by DHEA at levels where cellular viability and DNA synthesis were not affected. At the concentrations tested DHEAS did not inhibit FIV replication or impact on cellular viability or proliferation.

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Citations

Mar 20, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A D DelpedroO Bakouche
Jul 29, 2008·Neurologic Clinics·Lysa BoisséChristopher Power
Jul 19, 2005·Veterinary Microbiology·German TejerizoEsperanza Gomez-Lucia
Aug 16, 2005·The Journal of General Virology·Chia-Che ChangChun-Jung Chen

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