PMID: 9003261Jan 1, 1997Paper

Dehydroepiandrosterone protects muscle flap microcirculatory hemodynamics from ischemia/reperfusion injury: an experimental in vivo study

The Journal of Trauma
R LohmanM Siemionow

Abstract

This study evaluated the potential for dehydroepiandrosterone (DHEA) to protect skeletal muscle from reperfusion injury using intravital microscopic observations of isolated rat cremaster muscle flaps. The flaps were subjected to warm ischemia followed by reperfusion in three groups of rats. In group 1 (control, n = 14), muscle flaps were subjected to 6 hours of ischemia and then evaluated after either 90 minutes (n = 8) or 24 hours (n = 6) of reperfusion. Group 2 animals (propylene glycol pretreatment, n = 8) were pretreated with a propylene glycol vehicle, then underwent 6 hours of ischemia and were evaluated after 90 minutes reperfusion. Group 3 animals (DHEA pretreatment, n = 12) were pretreated with DHEA dissolved in propylene glycol, subjected to 6 hours of ischemia, and then evaluated after either 90 minutes (n = 6) or 24 hours (n = 6) of reperfusion. Red blood cell velocity in the flap's main arteriole, functional capillary density, venular constriction index (the ratio of internal to external diameter of postcapillary venules), and microemboli formation were measured. Muscle samples were evaluated by electron microscopy. Control animals showed a 61% reduction in red blood cell velocity (p < 0.05) accompanied by a 69% r...Continue Reading

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Citations

May 4, 2010·Journal of Rehabilitation Research and Development·John A RussellGregory K Hartig
Feb 17, 2006·Anaesthesia·S TurnerUNKNOWN Leeds Liver Transplant Group
Apr 1, 2000·Plastic and Reconstructive Surgery·J L LarsonW A Zamboni
Dec 13, 2006·The Journal of Trauma·Rongjie YangCharles W Van Way
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Stuart J HutchisonKrishnankutty Sudhir
Mar 24, 2005·Treatments in Endocrinology·Deborah R Cameron, Glenn D Braunstein

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