Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men

The American Journal of the Medical Sciences
N A BeerJ E Nestler

Abstract

Dehydroepiandrosterone (DHEA) may help prevent heart disease in men. To test the hypothesis that DHEA might exert its effects by enhancing endogenous fibrinolytic potential, a double-blind, placebo-controlled study was conducted that assessed the effects of DHEA administration on plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigen. Eighteen men received 50 mg DHEA orally and 16 men received a placebo capsule thrice daily for 12 days. Serum DHEA-sulfate and plasma PAI-1 and tPA antigen were measured before and after treatment. In the DHEA group, serum DHEA-sulfate (from 7.5 +/- 1.2 micromol/L to 20.2 +/- 1.5 micromol/L (P < 0.0001), androstenedione (from 2.6 +/- 0.2 nmol/L to 4.0 +/- 0.4 nmol/L; P < 0.005) and estrone (from 172 +/- 21 pmol/L to 352 +/- 28 pmol/L; P < 0.005) increased, whereas plasma PAI-1 (from 55.4 +/- 3.8 ng/mL to 38.6 +/- 3.3 ng/mL; P < 0.0001) and tPA antigen (from 8.1 +/- 1.9 ng/mL to 5.4 +/- 1.3 ng/mL; P < 0.0005) decreased. In the placebo group, serum DHEA-sulfate declined slightly from 8.0 +/- 3.3 micromol/L to 7.3 +/- 3.4 micromol/L (P < 0.05), but no other measured steroid changed. Plasma PAI-1 and tPA antigen did not change in the placebo group. These f...Continue Reading

References

Jun 1, 1992·The American Journal of the Medical Sciences·E S BrowneF Svec
Sep 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J E NestlerW G Blackard
Nov 1, 1990·Journal of the American College of Cardiology·D M HerringtonT A Pearson
Mar 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y AradH N Ginsberg
Dec 11, 1986·The New England Journal of Medicine·E Barrett-ConnorS S Yen
Nov 1, 1986·Journal of Molecular and Cellular Cardiology·M MayerM Chaouat
Feb 27, 1987·Biochemical and Biophysical Research Communications·D PearsonY Nagamine
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman

❮ Previous
Next ❯

Citations

Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·F Svec
May 20, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Richard D JonesKevin S Channer
Aug 29, 2009·Journal of Atherosclerosis and Thrombosis·Tadashi YamakawaYasuo Terauchi
Dec 12, 2012·ISRN Cardiology·Karina W Davidson
Jul 26, 2003·QJM : Monthly Journal of the Association of Physicians·C J MalkinK S Channer
Oct 29, 2011·The Journal of Sexual Medicine·Abdulmaged M TraishAndre T Guay
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·E H LiuM C Oz
Jun 8, 2012·Physiological Research·A GarridoL Valladares

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.