Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli

Glia
Z HoykL M Garcia-Segura

Abstract

Effects of dehydroepiandrosterone (DHEA) on glial reactions of the peripherally denervated olfactory bulb were studied in adult male rats. Denervation was achieved by destroying the olfactory mucosa with ZnSO(4) (0.17 M) irrigation of the nasal cavities. In one series of experiments, chronic DHEA treatment was applied (daily injections for 7 days, i.p., 10 mg/kg b.w. and 25 mg/kg b.w.); in the other series of experiments, animals received a single injection of DHEA (i.p., 10 mg/kg b.w., 25 mg/kg b.w. and 50 mg/kg b.w.) 2 h following ZnSO(4) treatment. To determine whether DHEA conversion to estradiol was involved in the mechanism of DHEA action on glia, a third series of experiments was carried out in which the aromatase inhibitor fadrozole (4.16 mg/ml) was administered using subcutaneously implanted osmotic minipumps. Rats were killed on day 7 after chemical denervation, and the reaction of glial cells was monitored within the olfactory bulb, using GFAP and vimentin immunohistochemistry. Qualitative changes in GFAP expression were analyzed by Western blot. Chronic DHEA treatment with both doses (10 mg/kg b.w. and 25 mg/kg b.w.) and acute DHEA treatment with the highest dose applied (50 mg/kg b.w.), inhibited the increase in GF...Continue Reading

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Citations

Apr 30, 2009·Seminars in Reproductive Medicine·Charles E RoselliPatricia D Hurn
Mar 10, 2012·Hormones and Behavior·María Angeles ArevaloLuis M Garcia-Segura
Jun 7, 2005·Journal of Neurochemistry·Cherkaouia KibalyAyikoe G Mensah-Nyagan
Mar 28, 2008·Journal of Neurochemistry·Bradley J Walters, Colin J Saldanha
Jul 8, 2008·Journal of Neuroendocrinology·L M Garcia-Segura
Aug 15, 2006·Glia·Luis M Garcia-Segura, Roberto C Melcangi
May 5, 2006·Journal of Neurobiology·Véronique SchaefferAyikoe G Mensah-Nyagan
Dec 17, 2011·Neuroscience Letters·Danielle Kaiser de SouzaLuiz Carlos Rios Kucharski
Jan 1, 2010·Hormone Molecular Biology and Clinical Investigation·Iñigo AzcoitiaLuis M Garcia-Segura

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