Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity

The Journal of Clinical Endocrinology and Metabolism
F CalliesB Allolio

Abstract

Studies in animals and humans using supraphysiological doses of dehydroepiandrosterone (DHEA) reported significant changes in body composition and carbohydrate metabolism. To investigate the metabolic action of a physiological DHEA replacement dose, we studied 24 women with adrenal insufficiency (AI; mean +/- SD age, 42.3 +/- 9.3 yr; duration of disease, 9.2 +/- 8.4 yr; body mass index, 23.4 +/- 4.0 kg/m(2)) in a double blind, placebo-controlled, randomized, cross-over design. They received 50 mg DHEA/day and placebo orally for 4 months each, with a 1 -month washout period. Measurements included fasting serum glucose, insulin, leptin, bone markers, anthropometric parameters determined by bioimpedance analysis, and exercise capacity as assessed by an incremental cycling test. DHEA did not induce any change in body mass index (placebo vs. DHEA, 23.3 +/- 4.1 vs. 23.2 +/- 3.9 kg/m(2); P = 0.39), parameters of body composition, or exercise capacity. However, compared with placebo, DHEA replacement led to a significant decrease in serum leptin (absolute change after 4 months, DHEA vs. placebo, -5.3 +/- 8.0 vs. 1.1 +/- 5.7 ng/mL; P = 0.01). This is most likely the result of the DHEA-induced normalization of circulating androgens. DHEA...Continue Reading

Associated Clinical Trials

Citations

Dec 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D von MühlenR Bettencourt
Apr 11, 2008·Der Internist·S Hahner, B Allolio
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Aug 19, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Benjamin Campbell
Sep 24, 2010·Andrologia·Andy PetroianuF H O C Rodrigues
Apr 19, 2005·Treatments in Endocrinology·Dennis T Villareal
Mar 24, 2005·Treatments in Endocrinology·Deborah R Cameron, Glenn D Braunstein
Sep 29, 2018·The Journal of Sports Medicine and Physical Fitness·Nicolas GravisseKatia Collomp
Dec 9, 2008·Acta Pharmacologica Sinica·Heng-hui ChengQiu-rong Ruan
Oct 5, 2006·The Journal of Clinical Endocrinology and Metabolism·Margaret E WiermanNanette Santoro
Jan 12, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kei FujiokaTatsuo Ishizuka
Sep 1, 2012·Expert Review of Endocrinology & Metabolism·Marie LebbeWiebke Arlt
Feb 5, 2016·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·David J HandelsmanDavid F Gerrard
Apr 2, 2004·Journal of Endocrinological Investigation·I LambrinoudakiG Creatsas
Jun 27, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Han LinXiaolin Long
Mar 11, 2004·Journal of Endocrinological Investigation·S LauretiF Santeusanio
Aug 1, 2013·Hormone Molecular Biology and Clinical Investigation·Joanna Karbowska, Zdzislaw Kochan
Aug 27, 2004·Drugs·Louis J G Gooren, Mathijs C M Bunck
Mar 13, 2021·Nature Reviews. Disease Primers·Stefanie HahnerMarcus Quinkler
Jun 8, 2021·Pulmonary Circulation·Thomas P WalshCorey E Ventetuolo
Apr 29, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Sumit BhagraK Sreekumaran Nair

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.