Dehydroepiandrosterone restores hepatocellular function and prevents liver damage in estrogen-deficient females following trauma and hemorrhage

The Journal of Surgical Research
Joachim F KueblerI H Chaudry

Abstract

Recent studies have shown that administration of the sex steroid dehydroepiandrosterone (DHEA) in males following trauma-hemorrhagic shock has salutary effects on the depressed cardiovascular and immunological functions under those conditions. Since the effects of sex steroids are gender specific, we examined whether administration of DHEA has any beneficial effects on hepatocellular function in female rats with low estrogen levels following trauma-hemorrhage. Ovariectomy was performed in female Sprague-Dawley rats 14 days prior to the experiments. The animals then underwent a 5-cm midline laparotomy and were subjected to hemorrhagic shock (40 mm Hg for 90 min). This was followed by fluid resuscitation (Ringer's lactate over 60 min) and administration of DHEA (30 mg/kg BW) or vehicle subcutaneously at the end of resuscitation. At 24 h after resuscitation hepatocellular function, i.e., clearance of indocyanine green (ICG), and hepatocyte damage (serum alanine aminotransferase) were measured. Plasma levels of DHEA and 17beta-estradiol were also assayed. Vehicle-treated rats had significantly reduced hepatocellular function, increased ALT activity, and decreased levels of 17beta-estradiol following trauma-hemorrhage compared to sh...Continue Reading

References

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Citations

Jan 10, 2006·Critical Care Clinics·Jeffrey I Mechanick, David M Nierman
May 6, 2004·The Journal of Surgical Research·Joachim F KueblerIrshad H Chaudry
May 11, 2005·The Journal of Surgical Research·Scott BantaMartin L Yarmush
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Edwin A DeitchCarl J Hauser
Oct 3, 2003·Journal of the American College of Surgeons·Leonidas G KoniarisTeresa A Zimmers

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