PMID: 8938260Feb 9, 1996Paper

Dehydroepiandrosterone sulfate inhibition of catecholamine secretion from bovine adrenal chromaffin cells

Neuroscience Letters
P S LiuH L Hsieh

Abstract

Dehydroepiandrosterone sulfate (DHEAS) dose-dependently inhibited [3H]norepinephrine (NE) secretion and the corresponding [Ca2+]i rise induced by the nicotinic receptor agonist 1,1-dimethyl-4-phenylpoperazimium (DMPP) in bovine chromaffin cells. DHEAS at 10 microM, the physiological concentration in human serum, significantly inhibited both the release of [3H]NE and the rise of [Ca2+]i induced by DMPP in chromaffin cells. DHEAS also inhibited the [3H]NE release induced by the Na+ channel activator veratridine. However, DHEAS did not affect either the [3H]NE release, or the corresponding [Ca2+]i rise induced by high K+. Moreover, DHEAS suppressed the [Na+]i rise induced by either DMPP or high K+ as monitored by the fluorescence 340/380 ratio of SBFI loaded chromaffin cells. Our results suggest that the inhibitory effects of DHEAS on secretion mainly occur at nicotinic receptors as well as at the voltage-dependent Na+ channels.

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Citations

Nov 27, 2002·European Journal of Pharmacology·Kenzo KudoTakeshi Kashimoto
Dec 24, 1997·Brain Research. Brain Research Reviews·H R Arias
Dec 22, 1999·Acta Physiologica Scandinavica·O Zinder, D E Dar
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Guey-Jen Lai, David P McCobb
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Flavie SicardStefan R Bornstein
May 23, 2014·The Journal of Steroid Biochemistry and Molecular Biology·M HillL Stárka
May 3, 2005·Brain Research·Siobhan M Armstrong, Edward L Stuenkel
Dec 20, 2005·Toxicology and Applied Pharmacology·Pei-Shan Liu, Yi-Yin Chen
Mar 7, 2012·Biochemical Pharmacology·M ChevalierJ P Savineau
Dec 7, 2010·Molecular and Cellular Endocrinology·Kuei-Fang ChungMonika Ehrhart-Bornstein
May 31, 2008·The Journal of Biological Chemistry·Gaspar A Fernández NievasSilvia S Antollini
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Martina WeiseDeborah P Merke
Feb 18, 2004·Journal of Biomedical Science·Pei-Shan Liu, Pe-Yo Wang

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