Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function

Atherosclerosis
Sumiko YoshidaToshio Matsumoto

Abstract

Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. However, its biological significance in atherosclerosis remains controversial. Therefore, the aim of this study was to determine whether DHEAS is associated with development of carotid atherosclerosis in subjects with cardiovascular risk factors. A total of 419 Japanese individuals (208 males and 211 females) were recruited from Tokushima University Hospital, Japan. In all subjects, maximum intima-media thickness (max-IMT) in all carotid arteries, and mean-IMT and mean blood flow volume (BFV) in the common carotid arteries (CCA) were measured by ultrasonography; endothelial function was assessed by flow-mediated vasodilation of the brachial artery (%FMD). Serum DHEAS and classical cardiovascular risk factors were also evaluated. Statistical significance was determined by multiple regression analysis to elucidate independent determinants of max-IMT, mean-IMT, mean CCA-BFV, and %FMD. Serum DHEAS levels were higher in males than in females. Multiple regression analysis revealed that DHEAS was an independent negative factor for both max-IMT and mean-IMT in males but not in females. In contrast, DHEAS was the sole positive factor ...Continue Reading

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Citations

Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rei ShibataNoriyuki Ouchi
Apr 12, 2012·The Journal of Endocrinology·Yasumasa IkedaToshio Matsumoto
Oct 27, 2011·Journal of Atherosclerosis and Thrombosis·Hirotsugu KurobeTetsuya Kitagawa
Aug 6, 2014·Clinical Interventions in Aging·Nikolaos SamarasFilippo Ongaro
Jan 10, 2014·Journal of Atherosclerosis and Thrombosis·Mizuho KinouchiToshio Matsumoto
May 25, 2013·Stroke; a Journal of Cerebral Circulation·Monik C JiménezKathryn M Rexrode
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Takehiro MichikawaToru Takebayashi
Oct 29, 2011·The Journal of Sexual Medicine·Abdulmaged M TraishAndre T Guay
Aug 9, 2011·Metabolism: Clinical and Experimental·Theodora PappaMaria Alevizaki
Nov 3, 2015·Journal of Atherosclerosis and Thrombosis·Sumiko YoshidaKen-Ichi Aihara
Mar 28, 2012·The Journal of Medical Investigation : JMI·Toshiyuki YasuiMinoru Irahara
Jan 30, 2015·Applied Biochemistry and Biotechnology·Songhee JeonJongpil Kim
May 1, 2015·International Journal of Endocrinology and Metabolism·Tiphaine MannicMichel Florian Rossier
Mar 8, 2013·International Journal of Cardiology·Judith S BrandYvonne T van der Schouw
Nov 16, 2012·European Journal of Preventive Cardiology·Bouwe P KrijtheJan Heeringa
Nov 13, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Caio Jordão TeixeiraCarla Roberta de Oliveira Carvalho
May 15, 2018·The World Journal of Men's Health·Ahmed I El-Sakka
Jan 31, 2019·Journal of Occupational Health·Tores Theorell

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