Abstract
The association of low serum dehydroepiandrosterone sulfate (DHEAS) levels with age, lifestyle, general health status indicators, and specific diseases was investigated in 436 men and 544 women of 65-97 yr old. In both sexes low serum DHEAS levels were associated with age, alcohol intake, number of current medications, and decreased thyroid function. Low DHEAS was also associated with low serum albumin in men and low systolic blood pressure in women. Compared to healthy men (n=106) age-adjusted serum DHEAS levels were significantly lower in men with atrial fibrillation, chronic obstructive lung disease, dementia, parkinsonism, cancer, diabetes, hypothyroidism, and in institutionalized men. Compared to healthy women (n=100) age-adjusted serum DHEAS levels were significantly lower in women with occlusive arterial disease, chronic obstructive lung disease, and osteoporosis. After controlling for differences in lifestyle and general health status parameters, low DHEAS levels remained statistically associated only with atrial fibrillation in men and osteoporosis in women, and it cannot be excluded that these association were spurious, due to multiple comparisons. These data suggest that in elderly people low serum DHEAS levels are m...Continue Reading
References
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J F Mortola, S S Yen
Dec 11, 1986·The New England Journal of Medicine·E Barrett-ConnorS S Yen
Jun 30, 1988·The New England Journal of Medicine·K T KhawE Barrett-Connor
Oct 1, 1986·Maturitas·C LongcopeC C Johnston
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Jul 1, 1974·The British Journal of Nutrition·J V Durnin, J Womersley
Jan 1, 1969·The Gerontologist·M P Lawton, E M Brody
Jan 1, 1970·The Gerontologist·S KatzR C Grotz
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman
Jul 1, 1980·Clinical Endocrinology·F BassiM Serio
Jan 1, 1982·Endocrine Reviews·L Wartofsky, K D Burman
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
May 1, 1995·Epidemiology·P A NewcombP M Marcus
Jun 11, 1994·Lancet·P Ebeling, V A Koivisto
Jan 1, 1995·Gerontology·S LegrainE E Baulieu
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·C BerrE E Baulieu
Jan 1, 1997·The British Journal of Nutrition·G RavagliaG Gasbarrini
Jan 1, 1997·European Journal of Clinical Pharmacology·J U Rosholm, K Christensen
May 16, 1998·Biological Psychiatry·K YaffeS Cummings
Oct 8, 1998·Journal of Clinical Epidemiology·C C HsiehD Trichopoulos
Jun 1, 1999·Age and Ageing·N ThomasA G Need
Jul 17, 1999·Age and Ageing·M BonnefoyJ R Lacour
Nov 24, 1999·Brain Research. Brain Research Reviews·O T Wolf, C Kirschbaum
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S KiechlQ Xu
Jun 14, 2000·Family Practice·L VeehofB M Jong
Feb 13, 2001·Mechanisms of Ageing and Development·G RavagliaD Cucinotta
Jun 30, 2001·Archives of Gerontology and Geriatrics. Supplement·G RavagliaG Cavalli
Citations
Jul 31, 2012·Aging Clinical and Experimental Research·Teruo NagayaToshio Okinaka
Dec 13, 2005·Psychopharmacology·Amira Pierucci-LaghaHenry R Kranzler
Sep 1, 2007·Age·Eric R BravermanKenneth Blum
Dec 4, 2003·Current Opinion in Pharmacology·Emanuela Binello, Catherine M Gordon
Mar 24, 2004·Experimental Gerontology·Dana A GleiI-Wen Liu
Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Majon MullerYvonne T van der Schouw
Apr 25, 2012·Rejuvenation Research·Paola FortiMarco Zoli
Mar 24, 2005·Treatments in Endocrinology·Deborah R Cameron, Glenn D Braunstein
Jul 3, 2007·Experimental Gerontology·Noreen Goldman, Dana A Glei
Apr 9, 2005·Epilepsia·Carlo Andrea GalimbertiGiovanni Murialdo
May 23, 2009·Journal of Cardiovascular Electrophysiology·Takayuki TsunedaHiroshi Inoue
May 29, 2004·Alcoholism, Clinical and Experimental Research·Aafje SierksmaHenk F J Hendriks
Aug 27, 2010·Annals of the New York Academy of Sciences·Michael L Traub, Nanette Santoro
Mar 1, 2016·Canadian Journal of Diabetes·Nicola VeroneseGiuseppe Sergi
May 7, 2005·Metabolism: Clinical and Experimental·Wataru KamedaTakeo Kato
Aug 25, 2005·Clinical Endocrinology·D KapoorT H Jones
Jun 5, 2003·Expert Opinion on Investigational Drugs·Joan T Merrill
Mar 12, 2015·Journal of the American College of Nutrition·Rachelle D RohwerYiqing Song
Jul 4, 2015·BMC Psychiatry·Stacey B ScottMartin J Sliwinski
Dec 3, 2011·Psychoneuroendocrinology·Bríain ó HartaighJos A Bosch
Nov 16, 2012·European Journal of Preventive Cardiology·Bouwe P KrijtheJan Heeringa
Jan 6, 2006·The International Journal of Neuroscience·T D ParsonsJ G Buckwalter
May 1, 2015·International Journal of Endocrinology and Metabolism·Tiphaine MannicMichel Florian Rossier
Mar 7, 2020·Journal of Medical Genetics·Lucija BrcicWilliam Davies
Dec 28, 2017·PloS One·Eleanor L WattsRuth C Travis
Oct 18, 2018·Journal of Neuroinflammation·Y S L Powrie, C Smith
Aug 26, 2003·The American Journal of Clinical Nutrition·Leonie K Heilbronn, Eric Ravussin
Oct 31, 2020·General and Comparative Endocrinology·Liuxi ChuHuihua Deng
Aug 25, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H GargaglioniLuis Gustavo A Patrone