Dehydroepiandrosterone sulfate suppresses hippocampal recurrent inhibition and synchronizes neuronal activity to theta rhythm

Hippocampus
Scott C Steffensen

Abstract

Several neurosteroids have proconvulsant and memory-enhancing properties and are potent modulators of the gamma-amino butyric acid (GABA) receptor/chloride-ionophore complex. The effects of in situ microelectrophoretic application of the natural sulfate ester of the neurosteroid dehydroepiandrosterone (DHEAS) on evoked field responses and single-unit activity were evaluated in the dentate gyrus and CA1 hippocampal subfield of halothane-anesthetized rats. The effects of endogenous stimulation of DHEAS by in situ micropressure application of Trilostane ((4 alpha, 5 alpha, 17 beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2- carbonitrile (WIN24540)), an inhibitor of 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD), the enzyme that metabolizes DHEAS, on evoked responses and cellular activity in the hippocampus were also investigated. In situ microelectrophoretic application of DHEAS or micropressure application of Trilostane into CA1 markedly increased population excitatory postsynaptic potential (pEPSP) slopes and population spike (PS) amplitudes. Neither DHEAS nor Trilostane altered dentate pEPSP slopes or PS amplitudes, but both increased the amplitude of a late component of the pEPSP. Both DHEAS and Trilostane abolished ...Continue Reading

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Citations

Jun 8, 2006·Cellular and Molecular Neurobiology·György LürJózsef Toldi
May 6, 1999·Brain Research Bulletin·S Aldred, R H Waring
Jul 15, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R F ButterworthS Ahboucha
Mar 17, 1998·Biochemical and Biophysical Research Communications·M Imamura, C Prasad

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