PMID: 7289545Jan 1, 1981

Dehydrogenase activity of the pentosephosphate pathway of carbohydrate oxidation and its interrelation with lipid metabolism in hypokinesia

Kosmicheskaia biologiia i aviakosmicheskaia meditsina
T M Lobova, P P Potapov


The experiments were carried out on 84 white rats. At the beginning of hypokinesia activity of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in the adipose tissue was decreased and in the liver, skeletal muscles and heart increased. On the 30th hypokinetic day the enzyme activity was nearly normal. The dehydrogenase activity increased by the 60th hypokinetic day in the adipose tissue and by the 90th day in the liver and heart, whereas in skeletal muscles it decreased at that experimental stage. After completion of hypokinesia the enzyme activity increased. Possible relationship between these changes in the enzyme activity and disorders of lipid metabolism during hypokinesia is discussed.

Related Concepts

Adaptation, Physiological
Enzyme Activation
Glucosephosphate Dehydrogenase
Phosphogluconate Dehydrogenase
Physical Restraint
Carbohydrate Metabolism
Lipid Metabolism

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