Feb 1, 1976

Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis

Proceedings of the Society for Experimental Biology and Medicine
N A SchorC E Dunlap

Abstract

The activities of the cytochrome c reductases and of the D-T diaphorase in rat Leydig cell tumors have been described. The increase in enzymatic activity of the NADH cytochrome c reductase activity in functional tumors derived from interstitial cells of the rat testis is interpreted as being possibly related to hydroxylation of steroids by the neoplastic cells. Meanwhile, the increase in the activity of the D-T diaphorase in the other tumor is interpreted as being an anaplerotic reaction to substitute for the deficient shuttles for the transfer of reducing equivalents from the cytoplasm to the mitochondria observed in tumors.

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Mentioned in this Paper

Cytochrome Reductases
Neoplastic Cell
Microsomes
Structure of Interstitial Cell of Leydig
Interstitial
Neoplasms
Leydig Cell Tumor
Dihydrolipoamide Dehydrogenase
Mitochondria
Cyct

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