Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K

Molecular Carcinogenesis
Ji Hoon LeeKi Won Lee

Abstract

Bioactive natural compounds from plant-derived sources have received substantial interest due to their potential therapeutic and preventive effects toward various human diseases. Licorice (Glycyrrhiza), a frequently-used component in traditional oriental medicines, has been incorporated into recipes not only to enhance taste, but also to treat various conditions including inflammation, chronic fatigue syndrome, and even cancer. Dehydroglyasperin C (DGC) is a major isoflavone found in the root of licorice. In the present study, we investigated the cancer chemopreventive effect of DGC and the underlying molecular mechanisms involved, by analyzing its effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation and cyclooxygenase (COX)-2 expression in JB6 P+ mouse epidermal cells. DGC treatment attenuated TPA-induced activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) transcriptional activation, two major regulators of TPA-induced cell transformation, and COX-2 expression. TPA-induced phosphorylation of p38, JNK1/2 and Akt was also suppressed by DGC. Kinase assay data revealed that DGC inhibited the kinase activity of MKK4 and PI3K and this outcome was due to direct physical binding with DGC. N...Continue Reading

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Citations

Aug 27, 2015·Cellular and Molecular Life Sciences : CMLS·Nawab John DarMuzamil Ahmad
Apr 15, 2017·Journal of Cellular Biochemistry·Jong-Eun KimKi Won Lee
Nov 13, 2017·Pharmacological Reports : PR·Song Hua XuanSoo Nam Park
Apr 4, 2020·Journal of Dietary Supplements·Deepa S Mandlik Ingawale, Ajay G Namdeo

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