Del Nido Cardioplegia Versus Cold Blood Cardioplegia in Adult Cardiac Surgery: Protocol for a Randomized Controlled Trial

JMIR Research Protocols
Jessica Garcia-SuarezAlberto Forteza Gil

Abstract

The use of cardioplegia solutions as a myocardial protection technique is essential during cardiac surgery with cardiopulmonary bypass. The del Nido cardioplegia solution (DNS) has been widely used as a myocardial preservation technique for pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. Its unique pharmacological features have created growing interest for adult cardiac surgery, especially for elderly patients or those with ventricular dysfunction who are more prone to ischemia-reperfusion injury. Ever since its implementation, several retrospective studies have been published to validate the efficacy, safety, and efficiency of DNS in adult patients undergoing coronary revascularization, valve replacement, or combined procedures. Recently, a meta-analysis based on nine retrospective studies was published claiming the noninferiority of DNS compared to other conventional cardioplegia solutions. Few prospective randomized studies have been conducted whose primary outcome was the assessment of DNS clinical efficacy compared to other solutions commonly used in adult patients. The aim of this randomized clinical trial is to assess the benefits of DNS compared to Cardi-Braun blood cardioplegia solution in cl...Continue Reading

Associated Clinical Trials

References

Jul 2, 1955·Lancet·D G MELROSEJ B BAKER
Jul 27, 2010·The Journal of Thoracic and Cardiovascular Surgery·Stacy B O'BlenesSusan Howlett
May 28, 2014·Journal of Cardiac Surgery·Robert A SorabellaIsaac George
Jul 28, 2016·Perfusion·Gustavo E Guajardo SalinasGerardo Rodriguez-Araujo
Sep 2, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yongnan LiBingren Gao
Nov 8, 2017·The Journal of Thoracic and Cardiovascular Surgery·Harold L Lazar
Dec 17, 2017·The Journal of Thoracic and Cardiovascular Surgery·Niv AdDavid Fitzgerald
Jul 31, 2019·The Journal of Thoracic and Cardiovascular Surgery·Krzysztof SanetraMarek Cisowski

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BETA
coronary artery bypass

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NCT04094168

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